Due to its extensive length, DNA is packaged into a protective chromatin structure known as the nucleosome. In order to carry out various cellular functions, nucleosomes must be disassembled, allowing access to the underlying DNA, and subsequently reassembled on completion of these processes. The assembly and disassembly of nucleosomes is dependent on the function of histone modifiers, chromatin remodelers and histone chaperones.
In this review, we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR/HIRA complex. In S. cerevisiae, the HIR complex is made up of the proteins Hir1, Hir2, Hir3 and Hpc2, which collectively act in transcriptional regulation, elongation, gene silencing, cellular senescence and even aging. This review presents an overview of the role of the HIR complex, in yeast as well as other organisms, in each of these processes, in order to give a better understanding of how nucleosome assembly is imperative for cellular homeostasis and genomic integrity. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
Nucleosome assembly factors CAF-1 and HIR modulate epigenetic switching frequencies in an H3K56 acetylation-associated manner in Candida albicans.
CAF-1 and HIR are highly conserved histone chaperone protein complexes that function in the assembly of nucleosomes onto chromatin. CAF-1 is characterized as having replication-coupled nucleosome activity, whereas the HIR complex can assemble nucleosomes independent of replication. Histone H3K56 acetylation, controlled by the acetyltransferase Rtt109 and deacetylase Hst3, also plays a significant role in nucleosome assembly. In this study, we generated a set of deletion mutants to genetically characterize pathway-specific and overlapping functions of CAF-1 and HIR in C. albicans. Their roles in epigenetic maintenance of cell type were examined by using the white-opaque switching system in C. albicans.
We show that CAF-1 and HIR play conserved roles in UV radiation recovery, repression of histone gene expression, correct chromosome segregation, and stress responses. Unique to C. albicans, the cac2Δ/Δ mutant shows increased sensitivity to the Hst3 inhibitor nicotinamide, while the rtt109Δ/Δ cac2Δ/Δ and hir1Δ/Δ cac2Δ/Δ mutants are resistant to nicotinamide.
CAF-1 plays a major role in maintaining cell types, as the cac2Δ/Δ mutant exhibited increased switching frequencies in both directions and switched at a high frequency to opaque in response to nicotinamide. Like the rtt109Δ/Δ mutant, the hir1Δ/Δ cac2Δ/Δ double mutant is defective in maintaining the opaque cell fate and blocks nicotinamide-induced opaque formation, and the defects are suppressed by ectopic expression of the master white-opaque regulator Wor1. Our data suggest an overlapping function of CAF-1 and HIR in epigenetic regulation of cell fate determination in an H3K56 acetylation-associated manner.
Visible infrared spin-scan radiometer atmospheric sounder radiometric calibration: an inflight evaluation from intercomparisons with HIRS and radiosonde measurements.
The Visible IR spin-scan radiometer Atmospheric Sounder (VAS) is the first sounding instrument placed in geostationary orbit. The calibration procedure for determining VAS radiances requires modeling the contributions of the telescope foreoptics components to the background radiation. A simple relation between target radiance and detector output voltage is derived.
The calibration procedure is successfully tested by comparisons with HIRS and radiosonde data. After removing a negative offset of up to 3 degrees C in three of the upper atmospheric CO(2) bands of VAS, the capability to produce accurate soundings (within 2 degrees C of radiosonde) was demonstrated.
The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.
The histone genes are an important group of cell cycle regulated genes whose transcription is activated during the G1/S transition and repressed in early G1, late S, and G2/M. The HIR complex, comprised of Hir1, Hir2, Hir3 and Hpc2, regulates three of the four histone gene loci. While relief of repression at the G1/S boundary involves the HIR complex, as well as other cofactors, the mechanism by which this derepression occurs remains unknown. To better understand how transcriptional repression contributes to periodic expression in the cell cycle, we sought to identify the cell cycle signals required to alleviate HIR-mediated repression of the histone genes.
CMV control lentivirus (Hygro) |
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| CMV-Null-Hygro | GenTarget | 1 x107 IFU/ml x 200ul | EUR 418.8 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter. |
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CMV control lentivirus (Zeo) |
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| CMV-Null-Zeo | GenTarget | 1 x107 IFU/ml x 200ul | EUR 418.8 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter. |
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HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA) |
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| LV627644 | ABM | 1.0 ug DNA | EUR 818.4 |
HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro) |
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| LV627645 | ABM | 1.0 ug DNA | EUR 888 |
HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro) |
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| LV627646 | ABM | 1.0 ug DNA | EUR 888 |
CMV Control lentiviral particles (Bsd) in PBS |
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| CMV-Null-Bsd-PBS | GenTarget | 1 x108 IFU/ml x 200ul | EUR 852 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the blasticidin marker under RSV promoter. The virus was concentrated and provided in PBS solution. |
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CMV Control lentiviral particles (Neo) in PBS |
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| CMV-Null-Neo-PBS | GenTarget | 1 x108 IFU/ml x 200ul | EUR 852 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Neomycin marker under RSV promoter. The virus was concentrated and provided in PBS solution. |
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CMV Control lentiviral particles (Puro) in PBS |
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| CMV-Null-Puro-PBS | GenTarget | 1 x108 IFU/ml x 200ul | EUR 852 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Puromycin marker under RSV promoter. The virus was concentrated and provided in PBS solution. |
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CMV Control lentiviral particles (GFP-Bsd) in PBS |
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| CMV-Null-GB-PBS | GenTarget | 1 x108 IFU/ml x 200ul | EUR 852 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution. |
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CMV Control lentiviral particles (GFP-Puro) in PBS |
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| CMV-Null-GP-PBS | GenTarget | 1 x108 IFU/ml x 200ul | EUR 852 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution. |
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CMV Control lentiviral particles (RFP-Bsd) in PBS |
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| CMV-Null-RB-PBS | GenTarget | 1 x108 IFU/ml x 200ul | EUR 852 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution. |
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CMV Control lentiviral particles (RFP-Puro) in PBS |
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| CMV-Null-RP-PBS | GenTarget | 1 x108 IFU/ml x 200ul | EUR 852 |
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Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution. |
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ERAF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810237 | ABM | 1.0 ug DNA | EUR 379.2 |
C6orf218 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810243 | ABM | 1.0 ug DNA | EUR 379.2 |
BXDC1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810249 | ABM | 1.0 ug DNA | EUR 379.2 |
C17orf45 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810255 | ABM | 1.0 ug DNA | EUR 379.2 |
FAM86C Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810261 | ABM | 1.0 ug DNA | EUR 379.2 |
C3orf31 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810267 | ABM | 1.0 ug DNA | EUR 379.2 |
C13orf16 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810279 | ABM | 1.0 ug DNA | EUR 379.2 |
C21ORF55 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810285 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ10357 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810291 | ABM | 1.0 ug DNA | EUR 379.2 |
C13orf3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810297 | ABM | 1.0 ug DNA | EUR 379.2 |
ARL17 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810303 | ABM | 1.0 ug DNA | EUR 379.2 |
HSPC047 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810309 | ABM | 1.0 ug DNA | EUR 379.2 |
C9orf68 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810315 | ABM | 1.0 ug DNA | EUR 379.2 |
C18orf22 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810321 | ABM | 1.0 ug DNA | EUR 379.2 |
KIAA0774 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810327 | ABM | 1.0 ug DNA | EUR 379.2 |
BXDC5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810333 | ABM | 1.0 ug DNA | EUR 379.2 |
IL8RA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810339 | ABM | 1.0 ug DNA | EUR 379.2 |
RBM9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810345 | ABM | 1.0 ug DNA | EUR 379.2 |
FAM62B Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810351 | ABM | 1.0 ug DNA | EUR 379.2 |
BC013798 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810357 | ABM | 1.0 ug DNA | EUR 379.2 |
RTCD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810363 | ABM | 1.0 ug DNA | EUR 379.2 |
TTC15 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810369 | ABM | 1.0 ug DNA | EUR 379.2 |
RAD51L1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810375 | ABM | 1.0 ug DNA | EUR 379.2 |
TSP50 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810381 | ABM | 1.0 ug DNA | EUR 379.2 |
TMEM22 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810387 | ABM | 1.0 ug DNA | EUR 379.2 |
KTELC1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810393 | ABM | 1.0 ug DNA | EUR 379.2 |
C9orf68 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810399 | ABM | 1.0 ug DNA | EUR 379.2 |
LASS4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810405 | ABM | 1.0 ug DNA | EUR 379.2 |
TMEM49 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810411 | ABM | 1.0 ug DNA | EUR 379.2 |
C2orf24 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810417 | ABM | 1.0 ug DNA | EUR 379.2 |
C1orf62 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810423 | ABM | 1.0 ug DNA | EUR 379.2 |
JMJD5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810429 | ABM | 1.0 ug DNA | EUR 379.2 |
AKD2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810435 | ABM | 1.0 ug DNA | EUR 379.2 |
WDR8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810441 | ABM | 1.0 ug DNA | EUR 379.2 |
LOC90379 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810447 | ABM | 1.0 ug DNA | EUR 379.2 |
SFRS17A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810453 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ13052 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810459 | ABM | 1.0 ug DNA | EUR 379.2 |
C6orf182 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810465 | ABM | 1.0 ug DNA | EUR 379.2 |
HNRPK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810471 | ABM | 1.0 ug DNA | EUR 379.2 |
C20ORF158 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810477 | ABM | 1.0 ug DNA | EUR 379.2 |
PCTK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810483 | ABM | 1.0 ug DNA | EUR 379.2 |
IGHGA1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810489 | ABM | 1.0 ug DNA | EUR 379.2 |
C8orf41 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810495 | ABM | 1.0 ug DNA | EUR 379.2 |
C19orf61 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810501 | ABM | 1.0 ug DNA | EUR 379.2 |
C10orf33 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810507 | ABM | 1.0 ug DNA | EUR 379.2 |
KIAA1434 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810513 | ABM | 1.0 ug DNA | EUR 379.2 |
LOC23117 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810519 | ABM | 1.0 ug DNA | EUR 379.2 |
C2orf67 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810525 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC10814 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810531 | ABM | 1.0 ug DNA | EUR 379.2 |
BC006419 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810537 | ABM | 1.0 ug DNA | EUR 379.2 |
C21orf122 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810543 | ABM | 1.0 ug DNA | EUR 379.2 |
BC007926 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810549 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ38668 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810555 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC13008 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810561 | ABM | 1.0 ug DNA | EUR 379.2 |
C12orf62 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810567 | ABM | 1.0 ug DNA | EUR 379.2 |
BC001867 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810573 | ABM | 1.0 ug DNA | EUR 379.2 |
Sep15 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810579 | ABM | 1.0 ug DNA | EUR 379.2 |
C14orf147 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810585 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC12966 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810591 | ABM | 1.0 ug DNA | EUR 379.2 |
LOC113386 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810597 | ABM | 1.0 ug DNA | EUR 379.2 |
LOC80154 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810603 | ABM | 1.0 ug DNA | EUR 379.2 |
LOC100132167 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810609 | ABM | 1.0 ug DNA | EUR 379.2 |
C4orf42 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810615 | ABM | 1.0 ug DNA | EUR 379.2 |
Selk Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810621 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC21881 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810627 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC13057 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810633 | ABM | 1.0 ug DNA | EUR 379.2 |
C18orf20 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810639 | ABM | 1.0 ug DNA | EUR 379.2 |
CXorf50B Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810645 | ABM | 1.0 ug DNA | EUR 379.2 |
C13orf36 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810651 | ABM | 1.0 ug DNA | EUR 379.2 |
NDR1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810657 | ABM | 1.0 ug DNA | EUR 379.2 |
C20orf30 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810663 | ABM | 1.0 ug DNA | EUR 379.2 |
C20orf30 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810669 | ABM | 1.0 ug DNA | EUR 379.2 |
Magmas Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810675 | ABM | 1.0 ug DNA | EUR 379.2 |
C6orf168 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810681 | ABM | 1.0 ug DNA | EUR 379.2 |
Dram Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810687 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ20897 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810693 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ14107 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810699 | ABM | 1.0 ug DNA | EUR 379.2 |
ZD52F10 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810705 | ABM | 1.0 ug DNA | EUR 379.2 |
SEDLP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810711 | ABM | 1.0 ug DNA | EUR 379.2 |
C14orf48 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810717 | ABM | 1.0 ug DNA | EUR 379.2 |
C6orf35 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810723 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC34034 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810729 | ABM | 1.0 ug DNA | EUR 379.2 |
C15ORF15 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810735 | ABM | 1.0 ug DNA | EUR 379.2 |
LOC339047 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV810741 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC31957 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810747 | ABM | 1.0 ug DNA | EUR 379.2 |
LOC153328 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810753 | ABM | 1.0 ug DNA | EUR 379.2 |
C3orf34 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810759 | ABM | 1.0 ug DNA | EUR 379.2 |
RANGNRF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810765 | ABM | 1.0 ug DNA | EUR 379.2 |
RANGNRF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810771 | ABM | 1.0 ug DNA | EUR 379.2 |
C18orf10 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810777 | ABM | 1.0 ug DNA | EUR 379.2 |
NAT13 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810783 | ABM | 1.0 ug DNA | EUR 379.2 |
C9orf61 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810789 | ABM | 1.0 ug DNA | EUR 379.2 |
FKSG24 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810795 | ABM | 1.0 ug DNA | EUR 379.2 |
C3orf60 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810801 | ABM | 1.0 ug DNA | EUR 379.2 |
C2orf7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810807 | ABM | 1.0 ug DNA | EUR 379.2 |
RWDD4A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810813 | ABM | 1.0 ug DNA | EUR 379.2 |
SAPS3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810819 | ABM | 1.0 ug DNA | EUR 379.2 |
Hdgfrp3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810825 | ABM | 1.0 ug DNA | EUR 379.2 |
MOBKL2B Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810837 | ABM | 1.0 ug DNA | EUR 379.2 |
RAB39 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810843 | ABM | 1.0 ug DNA | EUR 379.2 |
C10orf58 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810849 | ABM | 1.0 ug DNA | EUR 379.2 |
PI31 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810855 | ABM | 1.0 ug DNA | EUR 379.2 |
C1orf142 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810861 | ABM | 1.0 ug DNA | EUR 379.2 |
VPS24 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810867 | ABM | 1.0 ug DNA | EUR 379.2 |
AK3L1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810873 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ25770 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810879 | ABM | 1.0 ug DNA | EUR 379.2 |
BC008939 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810885 | ABM | 1.0 ug DNA | EUR 379.2 |
GPR175 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810891 | ABM | 1.0 ug DNA | EUR 379.2 |
C1orf190 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810897 | ABM | 1.0 ug DNA | EUR 379.2 |
C20orf12 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810903 | ABM | 1.0 ug DNA | EUR 379.2 |
C18orf55 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810909 | ABM | 1.0 ug DNA | EUR 379.2 |
SFRS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810915 | ABM | 1.0 ug DNA | EUR 379.2 |
ZNF509 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810921 | ABM | 1.0 ug DNA | EUR 379.2 |
FRAG1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810927 | ABM | 1.0 ug DNA | EUR 379.2 |
Nip30 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810933 | ABM | 1.0 ug DNA | EUR 379.2 |
C18orf24 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810939 | ABM | 1.0 ug DNA | EUR 379.2 |
PLUNC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810945 | ABM | 1.0 ug DNA | EUR 379.2 |
UNC84A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810951 | ABM | 1.0 ug DNA | EUR 379.2 |
C20orf39 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810957 | ABM | 1.0 ug DNA | EUR 379.2 |
C1orf89 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810963 | ABM | 1.0 ug DNA | EUR 379.2 |
Seli Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810969 | ABM | 1.0 ug DNA | EUR 379.2 |
TINP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810975 | ABM | 1.0 ug DNA | EUR 379.2 |
SRrp35 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810981 | ABM | 1.0 ug DNA | EUR 379.2 |
C1orf71 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810987 | ABM | 1.0 ug DNA | EUR 379.2 |
HEL308 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810993 | ABM | 1.0 ug DNA | EUR 379.2 |
WDR42A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV810999 | ABM | 1.0 ug DNA | EUR 379.2 |
C12orf24 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811005 | ABM | 1.0 ug DNA | EUR 379.2 |
C9orf30 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811011 | ABM | 1.0 ug DNA | EUR 379.2 |
DIMT1L Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811017 | ABM | 1.0 ug DNA | EUR 379.2 |
FAM164C Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811023 | ABM | 1.0 ug DNA | EUR 379.2 |
CCDC5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811029 | ABM | 1.0 ug DNA | EUR 379.2 |
C14orf104 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811035 | ABM | 1.0 ug DNA | EUR 379.2 |
MUDENG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811041 | ABM | 1.0 ug DNA | EUR 379.2 |
Sc4mol Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811047 | ABM | 1.0 ug DNA | EUR 379.2 |
HNRPC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811053 | ABM | 1.0 ug DNA | EUR 379.2 |
HNRPC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811059 | ABM | 1.0 ug DNA | EUR 379.2 |
MCART1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811065 | ABM | 1.0 ug DNA | EUR 379.2 |
CDC2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811071 | ABM | 1.0 ug DNA | EUR 379.2 |
C5orf35 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811077 | ABM | 1.0 ug DNA | EUR 379.2 |
C1orf102 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811083 | ABM | 1.0 ug DNA | EUR 379.2 |
SGEF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811089 | ABM | 1.0 ug DNA | EUR 379.2 |
SUNC1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811095 | ABM | 1.0 ug DNA | EUR 379.2 |
HNRPA0 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811101 | ABM | 1.0 ug DNA | EUR 379.2 |
TADA2L Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811107 | ABM | 1.0 ug DNA | EUR 379.2 |
PXMP3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811113 | ABM | 1.0 ug DNA | EUR 379.2 |
PB1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811119 | ABM | 1.0 ug DNA | EUR 379.2 |
HNRPC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811125 | ABM | 1.0 ug DNA | EUR 379.2 |
AKR1CL2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811131 | ABM | 1.0 ug DNA | EUR 379.2 |
GPSN2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811137 | ABM | 1.0 ug DNA | EUR 379.2 |
NARG1L Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811143 | ABM | 1.0 ug DNA | EUR 379.2 |
SCYE1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811149 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ11151 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811155 | ABM | 1.0 ug DNA | EUR 379.2 |
MORG1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811161 | ABM | 1.0 ug DNA | EUR 379.2 |
Perld1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811167 | ABM | 1.0 ug DNA | EUR 379.2 |
JTV1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811173 | ABM | 1.0 ug DNA | EUR 379.2 |
RICS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811179 | ABM | 1.0 ug DNA | EUR 379.2 |
CDC2L5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811185 | ABM | 1.0 ug DNA | EUR 379.2 |
FAM164A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811191 | ABM | 1.0 ug DNA | EUR 379.2 |
GBL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811197 | ABM | 1.0 ug DNA | EUR 379.2 |
RAD51L3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811203 | ABM | 1.0 ug DNA | EUR 379.2 |
C19orf62 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811209 | ABM | 1.0 ug DNA | EUR 379.2 |
BC011600 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811215 | ABM | 1.0 ug DNA | EUR 379.2 |
MOSC2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811221 | ABM | 1.0 ug DNA | EUR 379.2 |
NARG1L Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811227 | ABM | 1.0 ug DNA | EUR 379.2 |
TADA1L Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811233 | ABM | 1.0 ug DNA | EUR 379.2 |
KIAA0174 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811239 | ABM | 1.0 ug DNA | EUR 379.2 |
WDR68 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811245 | ABM | 1.0 ug DNA | EUR 379.2 |
SFRS6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811251 | ABM | 1.0 ug DNA | EUR 379.2 |
FLJ23049 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811257 | ABM | 1.0 ug DNA | EUR 379.2 |
CCDC109A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811263 | ABM | 1.0 ug DNA | EUR 379.2 |
FAM29A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811269 | ABM | 1.0 ug DNA | EUR 379.2 |
BC033514 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811275 | ABM | 1.0 ug DNA | EUR 379.2 |
CCDC123 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811281 | ABM | 1.0 ug DNA | EUR 379.2 |
BAT4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811287 | ABM | 1.0 ug DNA | EUR 379.2 |
BC035694 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811293 | ABM | 1.0 ug DNA | EUR 379.2 |
PECI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811299 | ABM | 1.0 ug DNA | EUR 379.2 |
IL8RB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811305 | ABM | 1.0 ug DNA | EUR 379.2 |
C14orf94 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811311 | ABM | 1.0 ug DNA | EUR 379.2 |
PECI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811317 | ABM | 1.0 ug DNA | EUR 379.2 |
WDR51A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811323 | ABM | 1.0 ug DNA | EUR 379.2 |
MGC26963 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811329 | ABM | 1.0 ug DNA | EUR 379.2 |
C1orf156 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811335 | ABM | 1.0 ug DNA | EUR 379.2 |
ARPM1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811341 | ABM | 1.0 ug DNA | EUR 379.2 |
ASAM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811347 | ABM | 1.0 ug DNA | EUR 379.2 |
FAM38A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811353 | ABM | 1.0 ug DNA | EUR 379.2 |
LASS3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811359 | ABM | 1.0 ug DNA | EUR 379.2 |
BC020564 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV811365 | ABM | 1.0 ug DNA | EUR 379.2 |
By measuring histone gene transcription in strains with various combinations of clb mutations, we found that the mitotic Clb1/Clb2 cyclins are required to alleviate Hir-mediated repression during the G1/S transition and that Clb2 physically interacts with the HIR complex. While the HIR complex regulates histone gene transcription in combination with two other histone H3/H4 chaperones, Asf1 and Rtt106, our data demonstrate that the mitotic Clb cyclins are necessary to specifically alleviate the repressive action of the HIR complex itself in order to allow proper expression of the histone genes in late G1/early S phase.