Due to its extensive length, DNA is packaged into a protective chromatin structure known as the nucleosome. In order to carry out various cellular functions, nucleosomes must be disassembled, allowing access to the underlying DNA, and subsequently reassembled on completion of these processes. The assembly and disassembly of nucleosomes is dependent on the function of histone modifiers, chromatin remodelers and histone chaperones.
In this review, we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR/HIRA complex. In S. cerevisiae, the HIR complex is made up of the proteins Hir1, Hir2, Hir3 and Hpc2, which collectively act in transcriptional regulation, elongation, gene silencing, cellular senescence and even aging. This review presents an overview of the role of the HIR complex, in yeast as well as other organisms, in each of these processes, in order to give a better understanding of how nucleosome assembly is imperative for cellular homeostasis and genomic integrity. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.
Nucleosome assembly factors CAF-1 and HIR modulate epigenetic switching frequencies in an H3K56 acetylation-associated manner in Candida albicans.
CAF-1 and HIR are highly conserved histone chaperone protein complexes that function in the assembly of nucleosomes onto chromatin. CAF-1 is characterized as having replication-coupled nucleosome activity, whereas the HIR complex can assemble nucleosomes independent of replication. Histone H3K56 acetylation, controlled by the acetyltransferase Rtt109 and deacetylase Hst3, also plays a significant role in nucleosome assembly. In this study, we generated a set of deletion mutants to genetically characterize pathway-specific and overlapping functions of CAF-1 and HIR in C. albicans. Their roles in epigenetic maintenance of cell type were examined by using the white-opaque switching system in C. albicans.
We show that CAF-1 and HIR play conserved roles in UV radiation recovery, repression of histone gene expression, correct chromosome segregation, and stress responses. Unique to C. albicans, the cac2Δ/Δ mutant shows increased sensitivity to the Hst3 inhibitor nicotinamide, while the rtt109Δ/Δ cac2Δ/Δ and hir1Δ/Δ cac2Δ/Δ mutants are resistant to nicotinamide.
CAF-1 plays a major role in maintaining cell types, as the cac2Δ/Δ mutant exhibited increased switching frequencies in both directions and switched at a high frequency to opaque in response to nicotinamide. Like the rtt109Δ/Δ mutant, the hir1Δ/Δ cac2Δ/Δ double mutant is defective in maintaining the opaque cell fate and blocks nicotinamide-induced opaque formation, and the defects are suppressed by ectopic expression of the master white-opaque regulator Wor1. Our data suggest an overlapping function of CAF-1 and HIR in epigenetic regulation of cell fate determination in an H3K56 acetylation-associated manner.
Visible infrared spin-scan radiometer atmospheric sounder radiometric calibration: an inflight evaluation from intercomparisons with HIRS and radiosonde measurements.
The Visible IR spin-scan radiometer Atmospheric Sounder (VAS) is the first sounding instrument placed in geostationary orbit. The calibration procedure for determining VAS radiances requires modeling the contributions of the telescope foreoptics components to the background radiation. A simple relation between target radiance and detector output voltage is derived.
The calibration procedure is successfully tested by comparisons with HIRS and radiosonde data. After removing a negative offset of up to 3 degrees C in three of the upper atmospheric CO(2) bands of VAS, the capability to produce accurate soundings (within 2 degrees C of radiosonde) was demonstrated.
The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.
The histone genes are an important group of cell cycle regulated genes whose transcription is activated during the G1/S transition and repressed in early G1, late S, and G2/M. The HIR complex, comprised of Hir1, Hir2, Hir3 and Hpc2, regulates three of the four histone gene loci. While relief of repression at the G1/S boundary involves the HIR complex, as well as other cofactors, the mechanism by which this derepression occurs remains unknown. To better understand how transcriptional repression contributes to periodic expression in the cell cycle, we sought to identify the cell cycle signals required to alleviate HIR-mediated repression of the histone genes.
C5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV704421 | ABM | 1.0 ug DNA | EUR 540 |
S7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV747677 | ABM | 1.0 ug DNA | Ask for price |
NP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV814299 | ABM | 1.0 ug DNA | EUR 540 |
P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV739457 | ABM | 1.0 ug DNA | Ask for price |
NA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV735845 | ABM | 1.0 ug DNA | Ask for price |
NM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV736283 | ABM | 1.0 ug DNA | Ask for price |
MS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV734267 | ABM | 1.0 ug DNA | Ask for price |
IV Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV730175 | ABM | 1.0 ug DNA | Ask for price |
XM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756071 | ABM | 1.0 ug DNA | Ask for price |
XS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756089 | ABM | 1.0 ug DNA | Ask for price |
HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701979 | ABM | 1.0 ug DNA | EUR 540 |
C8A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702501 | ABM | 1.0 ug DNA | EUR 540 |
MIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV706503 | ABM | 1.0 ug DNA | EUR 540 |
AEN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707157 | ABM | 1.0 ug DNA | EUR 379.2 |
AEN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707163 | ABM | 1.0 ug DNA | EUR 379.2 |
AGK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707187 | ABM | 1.0 ug DNA | EUR 379.2 |
ALB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707271 | ABM | 1.0 ug DNA | EUR 379.2 |
ANG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707325 | ABM | 1.0 ug DNA | EUR 379.2 |
ATM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707655 | ABM | 1.0 ug DNA | EUR 379.2 |
BID Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707847 | ABM | 1.0 ug DNA | EUR 379.2 |
BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707871 | ABM | 1.0 ug DNA | EUR 379.2 |
BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV707877 | ABM | 1.0 ug DNA | EUR 379.2 |
CA8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708255 | ABM | 1.0 ug DNA | EUR 379.2 |
CA8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708261 | ABM | 1.0 ug DNA | EUR 379.2 |
CBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708339 | ABM | 1.0 ug DNA | EUR 379.2 |
CBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708345 | ABM | 1.0 ug DNA | EUR 379.2 |
CGA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708669 | ABM | 1.0 ug DNA | EUR 379.2 |
CKB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708753 | ABM | 1.0 ug DNA | EUR 379.2 |
CRK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708987 | ABM | 1.0 ug DNA | EUR 379.2 |
CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708993 | ABM | 1.0 ug DNA | EUR 379.2 |
CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV708999 | ABM | 1.0 ug DNA | EUR 379.2 |
DTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV709467 | ABM | 1.0 ug DNA | EUR 379.2 |
LY9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV705291 | ABM | 1.0 ug DNA | EUR 540 |
DUT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV705459 | ABM | 1.0 ug DNA | EUR 540 |
NPL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV705585 | ABM | 1.0 ug DNA | EUR 540 |
BMF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV705639 | ABM | 1.0 ug DNA | EUR 540 |
FTO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV705999 | ABM | 1.0 ug DNA | EUR 540 |
TK1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715875 | ABM | 1.0 ug DNA | EUR 379.2 |
UBB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV716529 | ABM | 1.0 ug DNA | EUR 379.2 |
CCT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV720665 | ABM | 1.0 ug DNA | Ask for price |
CCV Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV720719 | ABM | 1.0 ug DNA | Ask for price |
Sp2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715317 | ABM | 1.0 ug DNA | EUR 379.2 |
Sp2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715323 | ABM | 1.0 ug DNA | EUR 379.2 |
Syk Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV715605 | ABM | 1.0 ug DNA | EUR 379.2 |
SLN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702969 | ABM | 1.0 ug DNA | EUR 540 |
CRP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV703479 | ABM | 1.0 ug DNA | EUR 540 |
NPL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV703695 | ABM | 1.0 ug DNA | EUR 540 |
LY9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV703815 | ABM | 1.0 ug DNA | EUR 540 |
AOM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV718865 | ABM | 1.0 ug DNA | Ask for price |
ATD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV719171 | ABM | 1.0 ug DNA | Ask for price |
FGA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV704103 | ABM | 1.0 ug DNA | EUR 540 |
NNT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV704253 | ABM | 1.0 ug DNA | EUR 379.2 |
WAC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV716727 | ABM | 1.0 ug DNA | EUR 379.2 |
AFA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV718313 | ABM | 1.0 ug DNA | Ask for price |
AIC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV718391 | ABM | 1.0 ug DNA | Ask for price |
TTK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV716385 | ABM | 1.0 ug DNA | EUR 379.2 |
ST2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749651 | ABM | 1.0 ug DNA | EUR 686.4 |
ST3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749657 | ABM | 1.0 ug DNA | Ask for price |
ST4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749669 | ABM | 1.0 ug DNA | Ask for price |
ST8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV749687 | ABM | 1.0 ug DNA | Ask for price |
RP6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV747185 | ABM | 1.0 ug DNA | Ask for price |
RSS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV747629 | ABM | 1.0 ug DNA | Ask for price |
S11 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV747683 | ABM | 1.0 ug DNA | Ask for price |
S12 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV747689 | ABM | 1.0 ug DNA | Ask for price |
SDU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV748127 | ABM | 1.0 ug DNA | Ask for price |
SEA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV748133 | ABM | 1.0 ug DNA | Ask for price |
TDD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV750293 | ABM | 1.0 ug DNA | Ask for price |
THM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV750401 | ABM | 1.0 ug DNA | Ask for price |
TOC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV750677 | ABM | 1.0 ug DNA | Ask for price |
PRS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV741749 | ABM | 1.0 ug DNA | Ask for price |
PRD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV741569 | ABM | 1.0 ug DNA | Ask for price |
FTX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV761753 | ABM | 1.0 ug DNA | EUR 1104 |
CPP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV759281 | ABM | 1.0 ug DNA | EUR 2148 |
CPQ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV759287 | ABM | 1.0 ug DNA | EUR 686.4 |
UTX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV814419 | ABM | 1.0 ug DNA | EUR 540 |
PB1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV815385 | ABM | 1.0 ug DNA | EUR 540 |
PB1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV811119 | ABM | 1.0 ug DNA | EUR 379.2 |
GBL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV811197 | ABM | 1.0 ug DNA | EUR 379.2 |
NLP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV811935 | ABM | 1.0 ug DNA | EUR 379.2 |
DCI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV812301 | ABM | 1.0 ug DNA | EUR 379.2 |
RIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV812619 | ABM | 1.0 ug DNA | EUR 379.2 |
HNT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV812739 | ABM | 1.0 ug DNA | EUR 379.2 |
DCI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV809319 | ABM | 1.0 ug DNA | EUR 379.2 |
GAS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV813447 | ABM | 1.0 ug DNA | EUR 379.2 |
GRN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710661 | ABM | 1.0 ug DNA | EUR 379.2 |
HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710829 | ABM | 1.0 ug DNA | EUR 379.2 |
HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710835 | ABM | 1.0 ug DNA | EUR 379.2 |
HYI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV711141 | ABM | 1.0 ug DNA | EUR 379.2 |
JTB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV711555 | ABM | 1.0 ug DNA | EUR 379.2 |
LBH Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV711897 | ABM | 1.0 ug DNA | EUR 379.2 |
LTF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712071 | ABM | 1.0 ug DNA | EUR 379.2 |
LUM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712083 | ABM | 1.0 ug DNA | EUR 379.2 |
LXN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712089 | ABM | 1.0 ug DNA | EUR 379.2 |
NF2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712731 | ABM | 1.0 ug DNA | EUR 379.2 |
NMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712773 | ABM | 1.0 ug DNA | EUR 379.2 |
OAT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712983 | ABM | 1.0 ug DNA | EUR 379.2 |
OS9 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV713019 | ABM | 1.0 ug DNA | EUR 379.2 |
EVL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV709839 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710247 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710253 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710259 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710265 | ABM | 1.0 ug DNA | EUR 379.2 |
FTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710271 | ABM | 1.0 ug DNA | EUR 379.2 |
FUZ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710289 | ABM | 1.0 ug DNA | EUR 379.2 |
GIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV710403 | ABM | 1.0 ug DNA | EUR 379.2 |
PDR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV739871 | ABM | 1.0 ug DNA | Ask for price |
PIH Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV740315 | ABM | 1.0 ug DNA | Ask for price |
NSX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV736493 | ABM | 1.0 ug DNA | Ask for price |
NT3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV736499 | ABM | 1.0 ug DNA | Ask for price |
OAP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV736655 | ABM | 1.0 ug DNA | Ask for price |
MSD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV734285 | ABM | 1.0 ug DNA | Ask for price |
OED Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV736703 | ABM | 1.0 ug DNA | Ask for price |
MAA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV732365 | ABM | 1.0 ug DNA | Ask for price |
MCO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV732641 | ABM | 1.0 ug DNA | Ask for price |
MEB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV732671 | ABM | 1.0 ug DNA | Ask for price |
mF4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV732743 | ABM | 1.0 ug DNA | Ask for price |
MLS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV733631 | ABM | 1.0 ug DNA | Ask for price |
MOK Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV733685 | ABM | 1.0 ug DNA | Ask for price |
KSS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV730745 | ABM | 1.0 ug DNA | Ask for price |
KWE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV730751 | ABM | 1.0 ug DNA | Ask for price |
LCO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV730883 | ABM | 1.0 ug DNA | Ask for price |
MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712167 | ABM | 1.0 ug DNA | EUR 379.2 |
MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712173 | ABM | 1.0 ug DNA | EUR 379.2 |
MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712179 | ABM | 1.0 ug DNA | EUR 379.2 |
MAX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712185 | ABM | 1.0 ug DNA | EUR 379.2 |
MPI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV712365 | ABM | 1.0 ug DNA | EUR 379.2 |
HMI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV728375 | ABM | 1.0 ug DNA | Ask for price |
HPT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV728723 | ABM | 1.0 ug DNA | Ask for price |
HTL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV728969 | ABM | 1.0 ug DNA | Ask for price |
PIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV713469 | ABM | 1.0 ug DNA | EUR 379.2 |
CHR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721169 | ABM | 1.0 ug DNA | Ask for price |
CMM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721403 | ABM | 1.0 ug DNA | Ask for price |
CNC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV721451 | ABM | 1.0 ug DNA | Ask for price |
COP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV721595 | ABM | 1.0 ug DNA | Ask for price |
CRG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV721781 | ABM | 1.0 ug DNA | Ask for price |
CRS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV721793 | ABM | 1.0 ug DNA | Ask for price |
CSE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV721835 | ABM | 1.0 ug DNA | Ask for price |
CTD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV721919 | ABM | 1.0 ug DNA | Ask for price |
GTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV727145 | ABM | 1.0 ug DNA | Ask for price |
GCY Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV726557 | ABM | 1.0 ug DNA | Ask for price |
JBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730193 | ABM | 1.0 ug DNA | Ask for price |
JPD Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730199 | ABM | 1.0 ug DNA | Ask for price |
KFM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730349 | ABM | 1.0 ug DNA | Ask for price |
KMS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
|||
| LV730469 | ABM | 1.0 ug DNA | Ask for price |
F7R Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV724757 | ABM | 1.0 ug DNA | Ask for price |
FND Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV725471 | ABM | 1.0 ug DNA | Ask for price |
DWS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV723515 | ABM | 1.0 ug DNA | Ask for price |
EBM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV723683 | ABM | 1.0 ug DNA | Ask for price |
EGI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV723929 | ABM | 1.0 ug DNA | Ask for price |
DM1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV723179 | ABM | 1.0 ug DNA | Ask for price |
DCE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV722333 | ABM | 1.0 ug DNA | Ask for price |
DDU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV722357 | ABM | 1.0 ug DNA | Ask for price |
PTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV713985 | ABM | 1.0 ug DNA | EUR 379.2 |
RGR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV714303 | ABM | 1.0 ug DNA | EUR 379.2 |
MPE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV733739 | ABM | 1.0 ug DNA | Ask for price |
TYS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV754913 | ABM | 1.0 ug DNA | Ask for price |
WTS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755999 | ABM | 1.0 ug DNA | Ask for price |
XCE Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756041 | ABM | 1.0 ug DNA | Ask for price |
XGR Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756047 | ABM | 1.0 ug DNA | Ask for price |
XIC Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756059 | ABM | 1.0 ug DNA | Ask for price |
VCF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755573 | ABM | 1.0 ug DNA | Ask for price |
VDI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755609 | ABM | 1.0 ug DNA | Ask for price |
WSN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755987 | ABM | 1.0 ug DNA | Ask for price |
WT2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV755993 | ABM | 1.0 ug DNA | Ask for price |
WWS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV756017 | ABM | 1.0 ug DNA | Ask for price |
RET Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV792597 | ABM | 1.0 ug DNA | EUR 379.2 |
SFN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV792783 | ABM | 1.0 ug DNA | EUR 379.2 |
TKT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV807481 | ABM | 1.0 ug DNA | EUR 379.2 |
TKT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV807487 | ABM | 1.0 ug DNA | EUR 379.2 |
NMB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV792189 | ABM | 1.0 ug DNA | EUR 379.2 |
OCLM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701079 | ABM | 1.0 ug DNA | EUR 540 |
ASIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701211 | ABM | 1.0 ug DNA | EUR 540 |
BEX1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701355 | ABM | 1.0 ug DNA | EUR 540 |
CIB2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701385 | ABM | 1.0 ug DNA | EUR 540 |
BTG2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701421 | ABM | 1.0 ug DNA | EUR 540 |
CIB3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701451 | ABM | 1.0 ug DNA | EUR 540 |
LHPP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701613 | ABM | 1.0 ug DNA | EUR 540 |
FBP2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701637 | ABM | 1.0 ug DNA | EUR 540 |
Selv Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701673 | ABM | 1.0 ug DNA | EUR 540 |
CTBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701739 | ABM | 1.0 ug DNA | EUR 540 |
ATF2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701769 | ABM | 1.0 ug DNA | EUR 540 |
EBF3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701805 | ABM | 1.0 ug DNA | EUR 540 |
ARSJ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701841 | ABM | 1.0 ug DNA | EUR 540 |
GRM2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701949 | ABM | 1.0 ug DNA | EUR 540 |
TUT1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701967 | ABM | 1.0 ug DNA | EUR 540 |
PKD2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV701973 | ABM | 1.0 ug DNA | EUR 540 |
E2F8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702057 | ABM | 1.0 ug DNA | EUR 540 |
UBA6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702099 | ABM | 1.0 ug DNA | EUR 540 |
WDR6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702141 | ABM | 1.0 ug DNA | EUR 540 |
INTU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702183 | ABM | 1.0 ug DNA | EUR 540 |
SAFB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702189 | ABM | 1.0 ug DNA | EUR 540 |
MIB1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702195 | ABM | 1.0 ug DNA | EUR 540 |
GRM4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702237 | ABM | 1.0 ug DNA | EUR 540 |
PHC2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702255 | ABM | 1.0 ug DNA | EUR 540 |
TSR1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702309 | ABM | 1.0 ug DNA | EUR 540 |
KIF6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702315 | ABM | 1.0 ug DNA | EUR 540 |
ChAT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702351 | ABM | 1.0 ug DNA | EUR 540 |
ChAT Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702447 | ABM | 1.0 ug DNA | EUR 540 |
TTC6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV) |
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| LV702453 | ABM | 1.0 ug DNA | EUR 540 |
By measuring histone gene transcription in strains with various combinations of clb mutations, we found that the mitotic Clb1/Clb2 cyclins are required to alleviate Hir-mediated repression during the G1/S transition and that Clb2 physically interacts with the HIR complex. While the HIR complex regulates histone gene transcription in combination with two other histone H3/H4 chaperones, Asf1 and Rtt106, our data demonstrate that the mitotic Clb cyclins are necessary to specifically alleviate the repressive action of the HIR complex itself in order to allow proper expression of the histone genes in late G1/early S phase.