A global requirement for the HIR complex in the assembly of chromatin.

Due to its extensive length, DNA is packaged into a protective chromatin structure known as the nucleosome. In order to carry out various cellular functions, nucleosomes must be disassembled, allowing access to the underlying DNA, and subsequently reassembled on completion of these processes. The assembly and disassembly of nucleosomes is dependent on the function of histone modifiers, chromatin remodelers and histone chaperones.
In this review, we discuss the roles of an evolutionarily conserved histone chaperone known as the HIR/HIRA complex. In S. cerevisiae, the HIR complex is made up of the proteins Hir1, Hir2, Hir3 and Hpc2, which collectively act in transcriptional regulation, elongation, gene silencing, cellular senescence and even aging. This review presents an overview of the role of the HIR complex, in yeast as well as other organisms, in each of these processes, in order to give a better understanding of how nucleosome assembly is imperative for cellular homeostasis and genomic integrity. This article is part of a Special Issue entitled: Histone chaperones and Chromatin assembly.

Nucleosome assembly factors CAF-1 and HIR modulate epigenetic switching frequencies in an H3K56 acetylation-associated manner in Candida albicans.

CAF-1 and HIR are highly conserved histone chaperone protein complexes that function in the assembly of nucleosomes onto chromatin. CAF-1 is characterized as having replication-coupled nucleosome activity, whereas the HIR complex can assemble nucleosomes independent of replication. Histone H3K56 acetylation, controlled by the acetyltransferase Rtt109 and deacetylase Hst3, also plays a significant role in nucleosome assembly. In this study, we generated a set of deletion mutants to genetically characterize pathway-specific and overlapping functions of CAF-1 and HIR in C. albicans. Their roles in epigenetic maintenance of cell type were examined by using the white-opaque switching system in C. albicans.
 A global requirement for the HIR complex in the assembly of chromatin.
We show that CAF-1 and HIR play conserved roles in UV radiation recovery, repression of histone gene expression, correct chromosome segregation, and stress responses. Unique to C. albicans, the cac2Δ/Δ mutant shows increased sensitivity to the Hst3 inhibitor nicotinamide, while the rtt109Δ/Δ cac2Δ/Δ and hir1Δ/Δ cac2Δ/Δ mutants are resistant to nicotinamide.
CAF-1 plays a major role in maintaining cell types, as the cac2Δ/Δ mutant exhibited increased switching frequencies in both directions and switched at a high frequency to opaque in response to nicotinamide. Like the rtt109Δ/Δ mutant, the hir1Δ/Δ cac2Δ/Δ double mutant is defective in maintaining the opaque cell fate and blocks nicotinamide-induced opaque formation, and the defects are suppressed by ectopic expression of the master white-opaque regulator Wor1. Our data suggest an overlapping function of CAF-1 and HIR in epigenetic regulation of cell fate determination in an H3K56 acetylation-associated manner.

Visible infrared spin-scan radiometer atmospheric sounder radiometric calibration: an inflight evaluation from intercomparisons with HIRS and radiosonde measurements.

The Visible IR spin-scan radiometer Atmospheric Sounder (VAS) is the first sounding instrument placed in geostationary orbit. The calibration procedure for determining VAS radiances requires modeling the contributions of the telescope foreoptics components to the background radiation. A simple relation between target radiance and detector output voltage is derived.
The calibration procedure is successfully tested by comparisons with HIRS and radiosonde data. After removing a negative offset of up to 3 degrees C in three of the upper atmospheric CO(2) bands of VAS, the capability to produce accurate soundings (within 2 degrees C of radiosonde) was demonstrated.

The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.

The histone genes are an important group of cell cycle regulated genes whose transcription is activated during the G1/S transition and repressed in early G1, late S, and G2/M. The HIR complex, comprised of Hir1, Hir2, Hir3 and Hpc2, regulates three of the four histone gene loci. While relief of repression at the G1/S boundary involves the HIR complex, as well as other cofactors, the mechanism by which this derepression occurs remains unknown. To better understand how transcriptional repression contributes to periodic expression in the cell cycle, we sought to identify the cell cycle signals required to alleviate HIR-mediated repression of the histone genes.

CMV control lentivirus (Hygro)

CMV-Null-Hygro 1 x107 IFU/ml x 200ul
EUR 418.8
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the hygromycin selection under RSV promoter.

CMV control lentivirus (Zeo)

CMV-Null-Zeo 1 x107 IFU/ml x 200ul
EUR 418.8
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It has the Zeocin selection under RSV promoter.

HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV627644 1.0 ug DNA
EUR 818.4

HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV627645 1.0 ug DNA
EUR 888

HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV627646 1.0 ug DNA
EUR 888

CMV Control lentiviral particles (Bsd) in PBS

CMV-Null-Bsd-PBS 1 x108 IFU/ml x 200ul
EUR 852
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the blasticidin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (Neo) in PBS

CMV-Null-Neo-PBS 1 x108 IFU/ml x 200ul
EUR 852
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Neomycin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (Puro) in PBS

CMV-Null-Puro-PBS 1 x108 IFU/ml x 200ul
EUR 852
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the Puromycin marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (GFP-Bsd) in PBS

CMV-Null-GB-PBS 1 x108 IFU/ml x 200ul
EUR 852
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (GFP-Puro) in PBS

CMV-Null-GP-PBS 1 x108 IFU/ml x 200ul
EUR 852
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the GFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (RFP-Bsd) in PBS

CMV-Null-RB-PBS 1 x108 IFU/ml x 200ul
EUR 852
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Blasticidin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

CMV Control lentiviral particles (RFP-Puro) in PBS

CMV-Null-RP-PBS 1 x108 IFU/ml x 200ul
EUR 852
Description: Negative control lentivirus contains a null spacer insert under CMV promoter, serves as the negative control of lentivurs treatment for the specificity of any target expression effects. It also has the RFP-Puromycin fusion marker under RSV promoter. The virus was concentrated and provided in PBS solution.

MT1P3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701007 1.0 ug DNA
EUR 540

LOC284297 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701013 1.0 ug DNA
EUR 540

LOC149837 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701019 1.0 ug DNA
EUR 540

GHRLOS2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701025 1.0 ug DNA
EUR 540

LINC00469 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701031 1.0 ug DNA
EUR 540

INGX Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701037 1.0 ug DNA
EUR 540

ABCA11P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701049 1.0 ug DNA
EUR 540

NCOR1P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701061 1.0 ug DNA
EUR 540

ZDHHC8P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701067 1.0 ug DNA
EUR 540

FLJ26850 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701073 1.0 ug DNA
EUR 540

OCLM Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701079 1.0 ug DNA
EUR 540

LINC00314 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701085 1.0 ug DNA
EUR 540

GSTTP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701091 1.0 ug DNA
EUR 540

LOC285679 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701097 1.0 ug DNA
EUR 540

VN1R3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701103 1.0 ug DNA
EUR 540

MT1DP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701115 1.0 ug DNA
EUR 540

LINC00313 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701127 1.0 ug DNA
EUR 540

LOC222699 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701139 1.0 ug DNA
EUR 540

LINC00161 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701145 1.0 ug DNA
EUR 540

LOC440419 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701151 1.0 ug DNA
EUR 540

KCNQ1DN Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701157 1.0 ug DNA
EUR 540

RBMS1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701175 1.0 ug DNA
EUR 540

MIR22HG Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701181 1.0 ug DNA Ask for price

C22orf34 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701187 1.0 ug DNA
EUR 540

ZNF663 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701193 1.0 ug DNA
EUR 540

AKR1CL1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701199 1.0 ug DNA
EUR 540

HMGB3P1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701205 1.0 ug DNA
EUR 540

ASIP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701211 1.0 ug DNA
EUR 540

LOC149950 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701217 1.0 ug DNA
EUR 540

BOLA2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701223 1.0 ug DNA
EUR 540

LOC441108 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701229 1.0 ug DNA
EUR 540

FLJ16126 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701235 1.0 ug DNA
EUR 540

LOC728032 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701241 1.0 ug DNA
EUR 540

C21orf67 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701253 1.0 ug DNA
EUR 540

TP53TG3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701259 1.0 ug DNA
EUR 540

OSTBETA Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701265 1.0 ug DNA
EUR 540

FLJ33360 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701271 1.0 ug DNA
EUR 540

LOC441208 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701277 1.0 ug DNA
EUR 540

C12orf36 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701283 1.0 ug DNA
EUR 540

LOC153684 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701289 1.0 ug DNA
EUR 540

LOC399900 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701295 1.0 ug DNA
EUR 540

LOC149134 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701301 1.0 ug DNA
EUR 540

LINC00173 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701313 1.0 ug DNA
EUR 540

LITAF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701319 1.0 ug DNA
EUR 540

HIST1H2AI Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701325 1.0 ug DNA
EUR 540

LOC440905 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701331 1.0 ug DNA
EUR 540

LOC339535 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701337 1.0 ug DNA
EUR 540

LOC643210 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701343 1.0 ug DNA
EUR 540

LOC440337 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701349 1.0 ug DNA
EUR 540

BEX1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701355 1.0 ug DNA
EUR 540

HIST2H2AA4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701361 1.0 ug DNA
EUR 540

LPAL2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701367 1.0 ug DNA
EUR 540

LOC340094 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701373 1.0 ug DNA
EUR 540

LINC00574 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701379 1.0 ug DNA
EUR 540

CIB2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701385 1.0 ug DNA
EUR 540

SNX12 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701397 1.0 ug DNA
EUR 540

FLJ44006 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701403 1.0 ug DNA
EUR 540

C15orf37 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701409 1.0 ug DNA
EUR 540

PLAC2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701415 1.0 ug DNA
EUR 540

BTG2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701421 1.0 ug DNA
EUR 540

FLJ40448 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701445 1.0 ug DNA
EUR 540

CIB3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701451 1.0 ug DNA
EUR 540

PRDX5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701457 1.0 ug DNA
EUR 540

FLJ45256 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701463 1.0 ug DNA
EUR 540

C21orf67 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701469 1.0 ug DNA
EUR 540

LINC00477 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701475 1.0 ug DNA
EUR 540

LOC348262 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701487 1.0 ug DNA
EUR 540

SHISA4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701493 1.0 ug DNA
EUR 540

LOC400707 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701499 1.0 ug DNA
EUR 540

FLJ41423 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701505 1.0 ug DNA
EUR 540

FLJ46257 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701511 1.0 ug DNA
EUR 540

FKSG83 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701517 1.0 ug DNA
EUR 540

FLJ25328 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701523 1.0 ug DNA
EUR 540

LOC84931 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701529 1.0 ug DNA
EUR 540

LOC389791 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701535 1.0 ug DNA
EUR 540

LOC338809 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701541 1.0 ug DNA
EUR 540

LOC441251 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701553 1.0 ug DNA
EUR 540

INSL6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701559 1.0 ug DNA
EUR 540

C1orf222 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701565 1.0 ug DNA
EUR 540

SFTPA2B Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701571 1.0 ug DNA
EUR 540

CCDC102B Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701595 1.0 ug DNA
EUR 540

C1QTNF3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701601 1.0 ug DNA
EUR 540

OTOGL Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701607 1.0 ug DNA
EUR 540

LHPP Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701613 1.0 ug DNA
EUR 540

TICAM2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701619 1.0 ug DNA
EUR 540

CHMP4A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701625 1.0 ug DNA
EUR 540

ALKBH3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701631 1.0 ug DNA
EUR 540

FBP2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701637 1.0 ug DNA
EUR 540

CLEC12A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701643 1.0 ug DNA
EUR 540

OR2C1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701649 1.0 ug DNA
EUR 540

TMEM182 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701655 1.0 ug DNA
EUR 540

LOC339524 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701661 1.0 ug DNA
EUR 540

SEPSECS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701667 1.0 ug DNA
EUR 540

Selv Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701673 1.0 ug DNA
EUR 540

GPR87 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701679 1.0 ug DNA
EUR 540

ASTN2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701685 1.0 ug DNA
EUR 540

MAGEB3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701691 1.0 ug DNA
EUR 540

SSTr4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701709 1.0 ug DNA
EUR 540

ACOT4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701715 1.0 ug DNA
EUR 540

ZNF672 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701721 1.0 ug DNA
EUR 540

SLC16A3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701727 1.0 ug DNA
EUR 540

CTBS Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701739 1.0 ug DNA
EUR 540

APOL1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701745 1.0 ug DNA
EUR 540

ST8SIA1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701751 1.0 ug DNA
EUR 540

MTERF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701757 1.0 ug DNA
EUR 540

ALG13 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701763 1.0 ug DNA
EUR 540

ATF2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701769 1.0 ug DNA
EUR 540

AHCYL1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701775 1.0 ug DNA
EUR 540

ZKSCAN1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701781 1.0 ug DNA
EUR 540

PTH1R Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701787 1.0 ug DNA
EUR 540

LOC553158 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701793 1.0 ug DNA
EUR 540

PIK3R2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701799 1.0 ug DNA
EUR 540

EBF3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701805 1.0 ug DNA
EUR 540

R3HDM2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701811 1.0 ug DNA
EUR 540

KCNN2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701817 1.0 ug DNA
EUR 540

SPIRE1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701823 1.0 ug DNA
EUR 540

TTC26 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701835 1.0 ug DNA
EUR 540

ARSJ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701841 1.0 ug DNA
EUR 540

SNX18 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701847 1.0 ug DNA
EUR 540

PYHIN1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701853 1.0 ug DNA
EUR 540

ZNF587 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701859 1.0 ug DNA
EUR 540

CDADC1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701865 1.0 ug DNA
EUR 540

FIP1L1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701871 1.0 ug DNA
EUR 540

GALNT3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701877 1.0 ug DNA
EUR 540

P4HA3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701889 1.0 ug DNA
EUR 540

IFFO1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701895 1.0 ug DNA
EUR 540

GRAMD4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701901 1.0 ug DNA
EUR 540

ZNF254 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701907 1.0 ug DNA
EUR 540

IREB2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701919 1.0 ug DNA
EUR 540

RBM26 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701925 1.0 ug DNA
EUR 540

ZBTB24 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701931 1.0 ug DNA
EUR 540

NLGN4Y Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701937 1.0 ug DNA
EUR 540

HSPA4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701943 1.0 ug DNA
EUR 540

GRM2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701949 1.0 ug DNA
EUR 540

EphA7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701955 1.0 ug DNA
EUR 540

TUT1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701967 1.0 ug DNA
EUR 540

PKD2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701973 1.0 ug DNA
EUR 540

HGF Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701979 1.0 ug DNA
EUR 540

MCTP2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701985 1.0 ug DNA
EUR 540

STON2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701991 1.0 ug DNA
EUR 540

C17orf70 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV701997 1.0 ug DNA
EUR 540

DDX27 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702003 1.0 ug DNA
EUR 540

C14orf49 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702009 1.0 ug DNA
EUR 540

MMS19 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702015 1.0 ug DNA
EUR 540

GUCY1A2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702021 1.0 ug DNA
EUR 540

WDR78 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702027 1.0 ug DNA
EUR 540

CLSTN3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702033 1.0 ug DNA
EUR 540

FLJ90650 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702039 1.0 ug DNA
EUR 540

SLC12A8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702045 1.0 ug DNA
EUR 540

ZNF616 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702051 1.0 ug DNA
EUR 540

E2F8 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702057 1.0 ug DNA
EUR 540

UBE3B Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702063 1.0 ug DNA
EUR 540

KIAA1429 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702069 1.0 ug DNA
EUR 540

CLIP1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702075 1.0 ug DNA
EUR 540

CENPJ Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702087 1.0 ug DNA
EUR 540

FYCO1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702093 1.0 ug DNA
EUR 540

UBA6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702099 1.0 ug DNA
EUR 540

RGS22 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702105 1.0 ug DNA
EUR 540

PITRM1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702111 1.0 ug DNA
EUR 540

IGF1R Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702117 1.0 ug DNA
EUR 540

CKAP5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702123 1.0 ug DNA
EUR 540

STXBP5 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702129 1.0 ug DNA
EUR 540

FBXO18 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702135 1.0 ug DNA
EUR 540

WDR6 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702141 1.0 ug DNA
EUR 540

TTC21A Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702147 1.0 ug DNA
EUR 540

PTPRO Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702153 1.0 ug DNA
EUR 540

NCOA3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702159 1.0 ug DNA
EUR 540

CORO7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702171 1.0 ug DNA
EUR 540

PSMD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702177 1.0 ug DNA
EUR 540

INTU Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702183 1.0 ug DNA
EUR 540

SAFB Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702189 1.0 ug DNA
EUR 540

MIB1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702195 1.0 ug DNA
EUR 540

CLCA4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702201 1.0 ug DNA
EUR 540

GPR133 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702207 1.0 ug DNA
EUR 540

C10orf118 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702213 1.0 ug DNA
EUR 540

FAM115C Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702219 1.0 ug DNA
EUR 540

VEPH1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702225 1.0 ug DNA
EUR 540

BCAS3 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702231 1.0 ug DNA
EUR 540

GRM4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702237 1.0 ug DNA
EUR 540

PHC2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702255 1.0 ug DNA
EUR 540

GPR128 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702261 1.0 ug DNA
EUR 540

PCDHB7 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702267 1.0 ug DNA
EUR 540

BARD1 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702273 1.0 ug DNA
EUR 540

DNAJC10 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702279 1.0 ug DNA
EUR 540

DPY19L4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702285 1.0 ug DNA
EUR 540

DNAJC10 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702291 1.0 ug DNA
EUR 540

CPEB4 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV702303 1.0 ug DNA
EUR 540
By measuring histone gene transcription in strains with various combinations of clb mutations, we found that the mitotic Clb1/Clb2 cyclins are required to alleviate Hir-mediated repression during the G1/S transition and that Clb2 physically interacts with the HIR complex. While the HIR complex regulates histone gene transcription in combination with two other histone H3/H4 chaperones, Asf1 and Rtt106, our data demonstrate that the mitotic Clb cyclins are necessary to specifically alleviate the repressive action of the HIR complex itself in order to allow proper expression of the histone genes in late G1/early S phase.

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