Overlapping regulation of CenH3 localization and histone H3 turnover by CAF-1 and HIR proteins in Saccharomyces cerevisiae.

Correct chromosome segregation relies on the centromere-specific histone H3 isoform identified usually as CenH3, or as Cse4 in budding yeast.…

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The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.

RNA polymerase II initiates from low complexity sequences so cells must reliably distinguish “real” from “cryptic” promoters and maintain fidelity…

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A global requirement for the HIR complex in the assembly of chromatin.

Due to its extensive length, DNA is packaged into a protective chromatin structure known as the nucleosome. In order to…

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The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.

Inadequate tissue oxygen, or hypoxia, is a central concept in the pathophysiology of ischemic disorders and cancer. Hypoxia promotes extracellular…

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