The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.

Inadequate tissue oxygen, or hypoxia, is a central concept in the pathophysiology of ischemic disorders and cancer. Hypoxia promotes extracellular matrix (ECM) remodeling, cellular metabolic adaptation, and cancer cell metastasis. To discover new pathways through which cells respond to hypoxia, we performed a large-scale forward genetic screen in Caenorhabditis elegans and identified a previously uncharacterized receptor tyrosine kinase named HIR-1.
Loss of function in hir-1 phenocopied the impaired ECM integrity associated with hypoxia or deficiency in the oxygen-dependent dual oxidase, heme peroxidases, or cuticular collagens involved in ECM homeostasis. Genetic suppressor screens identified NHR-49 and MDT-15 as transcriptional regulators downstream of HIR-1.
Furthermore, hir-1 mutants showed defects in adapting to and recovering from prolonged severe hypoxia. We propose that C. elegans HIR-1 coordinates hypoxia-inducible factor-independent responses to hypoxia and hypoxia-associated ECM remodeling through mechanisms that are likely conserved in other organisms.

The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals.

Morphological plasticity such as the yeast-to-hyphae transition is a key virulence factor of the human fungal pathogen Candida albicans. Hyphal formation is controlled by a multilayer regulatory network composed of environmental sensing, signaling, transcriptional modulators as well as chromatin modifications. Here, we demonstrate a novel role for the replication-independent HIR histone chaperone complex in fungal morphogenesis. HIR operates as a crucial modulator of hyphal development, since genetic ablation of the HIR complex subunit Hir1 decreases sensitivity to morphogenetic stimuli.
 The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.
Strikingly, HIR1-deficient cells display altered transcriptional amplitudes upon hyphal initiation, suggesting that Hir1 affects transcription by establishing transcriptional thresholds required for driving morphogenetic cell-fate decisions. Furthermore, ectopic expression of the transcription factor Ume6, which facilitates hyphal maintenance, rescues filamentation defects of hir1Δ/Δ cells, suggesting that Hir1 impacts the early phase of hyphal initiation. Hence, chromatin chaperone-mediated fine-tuning of transcription is crucial for driving morphogenetic conversions in the fungal pathogen C. albicans.

The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast.

In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by homologous recombination takes place in a nucleosomal environment. Nucleosomes may represent an obstacle for the recombination machinery and their timely eviction and reincorporation into chromatin may influence the outcome of recombination, for instance by stabilizing recombination intermediates.
Here we show in budding yeast that nucleosomes flanking a meiotic DSB are transiently lost during recombination, and that specific histone H3 chaperones, CAF-1 and Hir, are mobilized at meiotic DSBs. However, the absence of these chaperones has no effect on meiotic recombination, suggesting that timely histone reincorporation following their eviction has no influence on the recombination outcome, or that redundant pathways are activated. This study is the first example of the involvement of histone H3 chaperones at naturally occurring, developmentally programmed DNA double-strand breaks.

The histone chaperone complex HIR maintains nucleosome occupancy and counterbalances impaired histone deposition in CAF-1 complex mutants.

Chromatin organization is essential for coordinated gene expression, genome stability, and inheritance of epigenetic information. The main components involved in chromatin assembly are specific complexes such as Chromatin Assembly Factor 1 (CAF-1) and Histone Regulator (HIR), which deposit histones in a DNA synthesis-dependent or -independent manner, respectively. Here, we characterize the role of the plant orthologs Histone Regulator A (HIRA), Ubinuclein (UBN) and Calcineurin Binding protein 1 (CABIN1), which constitute the HIR complex.
Arabidopsis loss-of-function mutants for the various subunits of the complex are viable, but hira mutants show reduced fertility. We show that loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions. Concomitantly, HIRA contributes to maintenance of silencing of pericentromeric repeats and certain transposons.
A genetic analysis based on crosses between mutants deficient in subunits of the CAF-1 and HIR complexes showed that simultaneous loss of both the CAF-1 and HIR histone H3 chaperone complexes severely affects plant survival, growth and reproductive development. Our results suggest that HIRA partially rescues impaired histone deposition in fas mutants to preserve nucleosome occupancy, implying plasticity in histone variant interaction and deposition.

Tissue-specific expression of a soybean hypersensitive-induced response (HIR) protein gene promoter.

A Glycine max gene encoding a putative protein similar to hypersensitive-induced response proteins (HIR) was identified as a gene with preferred expressions in flowers and developing seeds by whole transcriptome gene expression profiling. Its promoter gm-hir1 was cloned and revealed to strongly express a fluorescence reporter gene primarily in integuments, anther tapetum, and seed coat with unique tissue-specificity. Expression in the inner integument was apparent prior to pollination, while expression in the outer integument started to develop from the micropylar end outward as the embryo matured.

Kv4.2 (phospho Ser616) Polyclonal Antibody

ES5998-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Kv4.2 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Kv4.2 (phospho Ser616) Polyclonal Antibody

ES5998-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Kv4.2 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2/KCND2 (Phospho-Ser616) Antibody

12447-100ul 100ul
EUR 252

Kv4.2/KCND2 (Phospho-Ser616) Antibody

12447-50ul 50ul
EUR 187

Phospho-Kv4.2/KCND2 (Ser616) Antibody

AF8074 200ul
EUR 376
Description: Kv4.2/KCND2 (Phospho-Ser616) Antibody detects endogenous levels of Kv4.2/KCND2 only when phosphorylated at Ser616.

Phospho-IRS-1 (Ser616) Antibody

AF4423 200ul
EUR 376
Description: Phospho-IRS-1 (Ser616) Antibody detects endogenous levels of IRS-1 only when phosphorylated at Ser616.

Kv4.2/KCND2 (Phospho- Ser616) Antibody

ABF8074 100 ug
EUR 438

IRS-1 (phospho Ser616) Polyclonal Antibody

ES5927-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser616) Polyclonal Antibody

ES5927-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser616) Polyclonal Antibody

ABP54928-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

IRS-1 (phospho Ser616) Polyclonal Antibody

ABP54928-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

IRS-1 (phospho Ser616) Polyclonal Antibody

ABP54928-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

DRP1 (Phospho-Ser616) Polyclonal Conjugated Antibody

C12749 100ul
EUR 397

Phospho-IRS1 (Ser312) Antibody

CSB-PA174165-
EUR 335
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser312) Antibody

CSB-PA174165-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser636) Antibody

CSB-PA577877-
EUR 335
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser636) Antibody

CSB-PA577877-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody

CSB-PA224848-
EUR 335
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody

CSB-PA224848-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Y896) Antibody

1-CSB-PA011243
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (Y896). Recognizes Phospho-IRS1 (Y896) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000

Phospho-IRS1 (S616) Antibody

1-CSB-PA011244
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S616). Recognizes Phospho-IRS1 (S616) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-IRS1 (S323) Antibody

1-CSB-PA011245
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S323). Recognizes Phospho-IRS1 (S323) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

Phospho-IRS1 (S1101) Antibody

1-CSB-PA000553
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S1101). Recognizes Phospho-IRS1 (S1101) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

Phospho-IRS1 (S307) Antibody

1-CSB-PA000554
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S307). Recognizes Phospho-IRS1 (S307) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-IRS1 (S307) Antibody

1-CSB-PA000555
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S307). Recognizes Phospho-IRS1 (S307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

Phospho-IRS1 (S636) Antibody

1-CSB-PA000556
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S636). Recognizes Phospho-IRS1 (S636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

Phospho-IRS1 (S639) Antibody

1-CSB-PA000557
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S639). Recognizes Phospho-IRS1 (S639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

Phospho-IRS1 (S794) Antibody

1-CSB-PA000558
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S794). Recognizes Phospho-IRS1 (S794) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

Phospho-IRS1 (S312) Antibody

1-CSB-PA000667
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S312). Recognizes Phospho-IRS1 (S312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/20000

Phospho-IRS1 (Ser639) Antibody

CSB-PA004394-
EUR 335
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser639) Antibody

CSB-PA004394-100ul 100ul
EUR 362
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-DRP1 (Ser616) Blocking Peptide

DF2972-BP 1mg
EUR 195

Phospho-DRP1 (Ser616) Blocking Peptide

AF8470-BP 1mg
EUR 195

Kv4.2/KCND2 (Phospho-Ser616) Polyclonal Conjugated Antibody

C12447 100ul
EUR 397

Phospho-IRS (Ser616) Antibody (Clone HIR-B1)

3105-100
EUR 359

Anti-Phospho-IRS1-(S307) antibody

STJ110879 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-S1101 antibody

STJ11101007 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-S323 antibody

STJ11101089 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S312) antibody

STJ22196 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S636) antibody

STJ22197 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S639) antibody

STJ22198 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S307) antibody

STJ22199 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Phospho-Kv4.2/KCND2 (Ser616) Blocking Peptide

AF8074-BP 1mg
EUR 195

Phospho-IRS-1 (Ser616) Blocking Peptide

AF4423-BP 1mg
EUR 195

KCND2 antibody (Ser616)

70R-35925 100 ug
EUR 327
Description: Rabbit polyclonal KCND2 antibody (Ser616)

anti-IRS1 (Phospho-Ser612)

LF-PA20649 100 ul
EUR 354
Description: Rabbit polyclonal to IRS1 (Phospho-Ser612)

Dynamin-1-Like Protein Phospho-Ser616 (DRP1) Antibody

20-abx149897
  • EUR 439.00
  • EUR 91.00
  • 100 ug
  • 10 ug

Anti-Phospho-IRS1-S636/639 antibody

STJ11101023 100 µl
EUR 393
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Hu-48T 48T
EUR 517
Description: A sandwich quantitative ELISA assay kit for detection of Human Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Hu-96T 96T
EUR 673
Description: A sandwich quantitative ELISA assay kit for detection of Human Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Mu-48T 48T
EUR 527
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Mu-96T 96T
EUR 688
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Ra-48T 48T
EUR 549
Description: A sandwich quantitative ELISA assay kit for detection of Rat Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Ra-96T 96T
EUR 718
Description: A sandwich quantitative ELISA assay kit for detection of Rat Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Hu-48Tests 48 Tests
EUR 544

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Hu-96Tests 96 Tests
EUR 756

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Mu-48Tests 48 Tests
EUR 557

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Mu-96Tests 96 Tests
EUR 774

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Ra-48Tests 48 Tests
EUR 583

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Ra-96Tests 96 Tests
EUR 811

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Hu-48Tests 48 Tests
EUR 521

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Hu-96Tests 96 Tests
EUR 723

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Mu-48Tests 48 Tests
EUR 533

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Mu-96Tests 96 Tests
EUR 740

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Ra-48Tests 48 Tests
EUR 557

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Ra-96Tests 96 Tests
EUR 775

Phospho-IRS1-S312 Rabbit pAb

AP0181-100ul 100 ul
EUR 384

Phospho-IRS1-S312 Rabbit pAb

AP0181-200ul 200 ul
EUR 554

Phospho-IRS1-S312 Rabbit pAb

AP0181-20ul 20 ul Ask for price

Phospho-IRS1-S312 Rabbit pAb

AP0181-50ul 50 ul
EUR 265

Phospho-IRS1-S636 Rabbit pAb

AP0225-100ul 100 ul
EUR 384

Phospho-IRS1-S636 Rabbit pAb

AP0225-200ul 200 ul
EUR 554

Phospho-IRS1-S636 Rabbit pAb

AP0225-20ul 20 ul Ask for price

Phospho-IRS1-S636 Rabbit pAb

AP0225-50ul 50 ul
EUR 265

Phospho-IRS1-S639 Rabbit pAb

AP0226-100ul 100 ul
EUR 384

Phospho-IRS1-S639 Rabbit pAb

AP0226-200ul 200 ul
EUR 554

Phospho-IRS1-S639 Rabbit pAb

AP0226-20ul 20 ul Ask for price

Phospho-IRS1-S639 Rabbit pAb

AP0226-50ul 50 ul
EUR 265

Phospho-IRS1-S307 Rabbit pAb

AP0371-100ul 100 ul
EUR 384

Phospho-IRS1-S307 Rabbit pAb

AP0371-200ul 200 ul
EUR 554

Phospho-IRS1-S307 Rabbit pAb

AP0371-20ul 20 ul Ask for price

Phospho-IRS1-S307 Rabbit pAb

AP0371-50ul 50 ul
EUR 265

Phospho-IRS1-S307 Rabbit pAb

AP0552-100ul 100 ul
EUR 384

Phospho-IRS1-S307 Rabbit pAb

AP0552-200ul 200 ul
EUR 554

Phospho-IRS1-S307 Rabbit pAb

AP0552-20ul 20 ul
EUR 183

Phospho-IRS1-S307 Rabbit pAb

AP0552-50ul 50 ul
EUR 265

Phospho-IRS1-S1101 Rabbit pAb

AP0867-100ul 100 ul
EUR 384

Phospho-IRS1-S1101 Rabbit pAb

AP0867-200ul 200 ul
EUR 554

Phospho-IRS1-S1101 Rabbit pAb

AP0867-20ul 20 ul
EUR 183
A 5′-deletion study showed that the promoter can be truncated to 600 bp long relative to the translation start site without affecting expression. A positive regulatory element was identified between 600 and 481 bp that controls expression in the inner integument, with no noticeable effect on expression in the outer integument or tapetum. Additionally, removal of the 5’UTR intron had no effect on levels or location of gm-hir1 expression while truncation to 370 bp resulted in a complete loss of expression suggesting that elements controlling both the outer integument and tapetum expression are located within the 481-370 bp region.

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