The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.

June 22, 2021 Leave a comment
Inadequate tissue oxygen, or hypoxia, is a central concept in the pathophysiology of ischemic disorders and cancer. Hypoxia promotes extracellular matrix (ECM) remodeling, cellular metabolic adaptation, and cancer cell metastasis. To discover new pathways through which cells respond to hypoxia, we performed a large-scale forward genetic screen in Caenorhabditis elegans and identified a previously uncharacterized receptor tyrosine kinase named HIR-1.
Loss of function in hir-1 phenocopied the impaired ECM integrity associated with hypoxia or deficiency in the oxygen-dependent dual oxidase, heme peroxidases, or cuticular collagens involved in ECM homeostasis. Genetic suppressor screens identified NHR-49 and MDT-15 as transcriptional regulators downstream of HIR-1.
Furthermore, hir-1 mutants showed defects in adapting to and recovering from prolonged severe hypoxia. We propose that C. elegans HIR-1 coordinates hypoxia-inducible factor-independent responses to hypoxia and hypoxia-associated ECM remodeling through mechanisms that are likely conserved in other organisms.

The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals.

Morphological plasticity such as the yeast-to-hyphae transition is a key virulence factor of the human fungal pathogen Candida albicans. Hyphal formation is controlled by a multilayer regulatory network composed of environmental sensing, signaling, transcriptional modulators as well as chromatin modifications. Here, we demonstrate a novel role for the replication-independent HIR histone chaperone complex in fungal morphogenesis. HIR operates as a crucial modulator of hyphal development, since genetic ablation of the HIR complex subunit Hir1 decreases sensitivity to morphogenetic stimuli.
The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.
Strikingly, HIR1-deficient cells display altered transcriptional amplitudes upon hyphal initiation, suggesting that Hir1 affects transcription by establishing transcriptional thresholds required for driving morphogenetic cell-fate decisions. Furthermore, ectopic expression of the transcription factor Ume6, which facilitates hyphal maintenance, rescues filamentation defects of hir1Δ/Δ cells, suggesting that Hir1 impacts the early phase of hyphal initiation. Hence, chromatin chaperone-mediated fine-tuning of transcription is crucial for driving morphogenetic conversions in the fungal pathogen C. albicans.

The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast.

In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by homologous recombination takes place in a nucleosomal environment. Nucleosomes may represent an obstacle for the recombination machinery and their timely eviction and reincorporation into chromatin may influence the outcome of recombination, for instance by stabilizing recombination intermediates.
Here we show in budding yeast that nucleosomes flanking a meiotic DSB are transiently lost during recombination, and that specific histone H3 chaperones, CAF-1 and Hir, are mobilized at meiotic DSBs. However, the absence of these chaperones has no effect on meiotic recombination, suggesting that timely histone reincorporation following their eviction has no influence on the recombination outcome, or that redundant pathways are activated. This study is the first example of the involvement of histone H3 chaperones at naturally occurring, developmentally programmed DNA double-strand breaks.

The histone chaperone complex HIR maintains nucleosome occupancy and counterbalances impaired histone deposition in CAF-1 complex mutants.

Chromatin organization is essential for coordinated gene expression, genome stability, and inheritance of epigenetic information. The main components involved in chromatin assembly are specific complexes such as Chromatin Assembly Factor 1 (CAF-1) and Histone Regulator (HIR), which deposit histones in a DNA synthesis-dependent or -independent manner, respectively. Here, we characterize the role of the plant orthologs Histone Regulator A (HIRA), Ubinuclein (UBN) and Calcineurin Binding protein 1 (CABIN1), which constitute the HIR complex.
Arabidopsis loss-of-function mutants for the various subunits of the complex are viable, but hira mutants show reduced fertility. We show that loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions. Concomitantly, HIRA contributes to maintenance of silencing of pericentromeric repeats and certain transposons.
A genetic analysis based on crosses between mutants deficient in subunits of the CAF-1 and HIR complexes showed that simultaneous loss of both the CAF-1 and HIR histone H3 chaperone complexes severely affects plant survival, growth and reproductive development. Our results suggest that HIRA partially rescues impaired histone deposition in fas mutants to preserve nucleosome occupancy, implying plasticity in histone variant interaction and deposition.

Tissue-specific expression of a soybean hypersensitive-induced response (HIR) protein gene promoter.

A Glycine max gene encoding a putative protein similar to hypersensitive-induced response proteins (HIR) was identified as a gene with preferred expressions in flowers and developing seeds by whole transcriptome gene expression profiling. Its promoter gm-hir1 was cloned and revealed to strongly express a fluorescence reporter gene primarily in integuments, anther tapetum, and seed coat with unique tissue-specificity. Expression in the inner integument was apparent prior to pollination, while expression in the outer integument started to develop from the micropylar end outward as the embryo matured.

IRS1 Antibody (phospho Ser312)
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IRS-1 (phospho Ser616) Polyclonal Antibody
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Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

IRS-1 (phospho Ser616) Polyclonal Antibody
ABP54928-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

IRS-1 (phospho Ser616) Polyclonal Antibody
ABP54928-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

IRS-1 (phospho Ser616) Polyclonal Antibody
E013782 100μg/100μl
EUR 255
Description: Available in various conjugation types.

IRS-1(Phospho Ser616) Polyclonal Antibody
BT-AP10511-100ul 100ul Ask for price
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

IRS-1(Phospho Ser616) Polyclonal Antibody
BT-AP10511-20ul 20ul Ask for price
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

IRS-1(Phospho Ser616) Polyclonal Antibody
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Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

IRS-1(Phospho Ser616) Polyclonal Antibody
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EUR 220

IRS-1(Phospho Ser616) Polyclonal Antibody
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IRS-1 (phospho Ser616) Polyclonal Antibody
E20-60640 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser616) Polyclonal Antibody
E44H01124 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

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IRS-1 (phospho Ser616) Polyclonal Antibody
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OASG03974-100UL - IRS1 Antibody (Phospho-Ser616)
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IRS (phospho Ser616) Polyclonal Antibody
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IRS (Phospho Ser616) Polyclonal Antibody
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IRS (Phospho Ser616) Polyclonal Antibody
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IRS-1 (phospho Ser616) Rabbit Polyclonal Antibody
ES5927-100ul 100ul
EUR 124
Description: WB, IHC, ELISA

IRS-1 (phospho Ser616) Rabbit Polyclonal Antibody
ES5927-50ul 50ul
EUR 74
Description: WB, IHC, ELISA

phospho-IRS1 (Ser616) Rabbit pAb
E47R12710 100ul
EUR 295

Phospho-IRS1 (Ser616) Blocking Peptide
MBS9616505-1mg 1mg
EUR 380

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Insulin Receptor Substrate 1 Phospho-Ser616 (IRS1 pS616) Antibody
20-abx329007
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  • 50 ug
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DRP1 (Phospho- Ser616) Antibody
ABF8470 100 ug
EUR 525.6

Phospho- DRP1 (Ser616) Antibody
ABD2972 100 ug
EUR 525.6

Phospho- DRP1 (Ser616) Antibody
ABD2981 100 ug
EUR 525.6

Phospho-DRP1 (Ser616) Antibody
DF2972 200ul
EUR 420

Phospho-DRP1 (Ser616) Antibody
DF2972-100ul 100ul
EUR 168
Description: WB,ELISA(peptide)

Phospho-DRP1 (Ser616) Antibody
DF2972-200ul 200ul
EUR 210
Description: WB,ELISA(peptide)

Phospho-DRP1 (Ser616) Antibody
AF8470 200ul
EUR 540

Phospho-DRP1 (Ser616) Antibody
AF8470-100ul 100ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-DRP1 (Ser616) Antibody
AF8470-200ul 200ul
EUR 270
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-DRP1 (Ser616) Antibody
E19-2972-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Phospho-DRP1 (Ser616) Antibody
E19-2972-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Phospho-DRP1 (Ser616) Antibody
MBS9614463-005mL 0.05mL
EUR 245

Phospho-DRP1 (Ser616) Antibody
MBS9614463-01mL 0.1mL
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Phospho-DRP1 (Ser616) Antibody
MBS8513652-01mLAF405M 0.1mL(AF405M)
EUR 465

Phospho-DRP1 (Ser616) Antibody
MBS8513652-01mLAF546 0.1mL(AF546)
EUR 465

Phospho-DRP1 (Ser616) Antibody
MBS8513652-01mLAF750 0.1mL(AF750)
EUR 465

Kv4.2/KCND2 (Phospho- Ser616) Antibody
ABF8074 100 ug
EUR 525.6

Kv4.2 (phospho Ser616) Polyclonal Antibody
ABP54999-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody
ABP54999-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody
ABP54999-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody
E013756 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Kv4.2(Phospho Ser616) Polyclonal Antibody
BT-AP10804-100ul 100ul Ask for price
Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as i

Kv4.2(Phospho Ser616) Polyclonal Antibody
BT-AP10804-20ul 20ul Ask for price
Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as i

Kv4.2(Phospho Ser616) Polyclonal Antibody
BT-AP10804-50ul 50ul Ask for price
Description: Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as i

Kv4.2(Phospho Ser616) Polyclonal Antibody
JOT-AP10804-100ul 100ul
EUR 220

Kv4.2(Phospho Ser616) Polyclonal Antibody
JOT-AP10804-50ul 50ul
EUR 144

Kv4.2 (phospho Ser616) Polyclonal Antibody
E44H00229 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

Kv4.2 (phospho Ser616) Polyclonal Antibody
E20-61005 100ug
EUR 225
Description: Available in various conjugation types.

Kv4.2 (phospho Ser616) Polyclonal Antibody
MBS8520779-01mg 0.1mg
EUR 305

Kv4.2 (phospho Ser616) Polyclonal Antibody
MBS8520779-01mLAF405L 0.1mL(AF405L)
EUR 465

Kv4.2 (phospho Ser616) Polyclonal Antibody
MBS8520779-01mLAF405S 0.1mL(AF405S)
EUR 465

Kv4.2 (phospho Ser616) Polyclonal Antibody
MBS8520779-01mLAF610 0.1mL(AF610)
EUR 465

Kv4.2 (phospho Ser616) Polyclonal Antibody
MBS8520779-01mLAF635 0.1mL(AF635)
EUR 465

Kv4.2 (Phospho Ser616) Polyclonal Antibody
MBS9458926-005mL 0.05mL
EUR 245

Kv4.2 (Phospho Ser616) Polyclonal Antibody
MBS9458926-01mL 0.1mL
EUR 305

Kv4.2 (Phospho Ser616) Polyclonal Antibody
MBS9458926-5x01mL 5x0.1mL
EUR 1230

Kv4.2 (phospho Ser616) Polyclonal Antibody
UB-GEN-15770 100 ul
EUR 200

Phospho-IRS-1 (Ser616) Antibody
E11-184423 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Phospho-IRS-1 (Ser616) Antibody
MBS8529055-01mg 0.1mg
EUR 305

Phospho-IRS-1 (Ser616) Antibody
MBS8529055-01mLAF405L 0.1mL(AF405L)
EUR 465

Phospho-IRS-1 (Ser616) Antibody
MBS8529055-01mLAF405S 0.1mL(AF405S)
EUR 465

Phospho-IRS-1 (Ser616) Antibody
MBS8529055-01mLAF610 0.1mL(AF610)
EUR 465

Phospho-IRS-1 (Ser616) Antibody
MBS8529055-01mLAF635 0.1mL(AF635)
EUR 465

Phospho-Kv4.2/KCND2 (Ser616) Antibody
AF8074 200ul
EUR 540

Phospho-Kv4.2/KCND2 (Ser616) Antibody
AF8074-100ul 100ul
EUR 210
Description: WB,IHC,ELISA(peptide)

Phospho-Kv4.2/KCND2 (Ser616) Antibody
AF8074-200ul 200ul
EUR 270
Description: WB,IHC,ELISA(peptide)

Phospho-Kv4.2/KCND2 (Ser616) Antibody
MBS9614075-005mL 0.05mL
EUR 245

Phospho-Kv4.2/KCND2 (Ser616) Antibody
MBS9614075-01mL 0.1mL
EUR 310

Phospho-Kv4.2/KCND2 (Ser616) Antibody
MBS9614075-02mL 0.2mL
EUR 370

Phospho-Kv4.2/KCND2 (Ser616) Antibody
MBS9614075-5x02mL 5x0.2mL
EUR 1605

IRS-1 (Phospho-Ser616) Antibody
A0447-100ul 100μl
EUR 217
Description: IRS-1 (Phospho-Ser616) Rabbit Polyclonal Antibody

IRS-1 (Phospho-Ser616) Antibody
A0447-50ul 50μl
EUR 143.5
Description: IRS-1 (Phospho-Ser616) Rabbit Polyclonal Antibody

Kv4.2 (phospho Ser616) Rabbit Polyclonal Antibody
ES5998-100ul 100ul
EUR 124
Description: IHC, ELISA

Kv4.2 (phospho Ser616) Rabbit Polyclonal Antibody
ES5998-50ul 50ul
EUR 74
Description: IHC, ELISA

IRS1 Antibody (phospho Tyr896)
GWB-F7F2BE 0.05 ml Ask for price

IRS1 Antibody (phospho Tyr941)
GWB-70BA06 0.05 ml Ask for price

IRS1 Antibody (phospho Tyr1179)
GWB-570DB1 0.05 ml Ask for price

Phospho-IRS1 (Ser1101) Antibody
AF4421 200ul
EUR 540

Phospho-IRS1 (Ser1101) Antibody
AF4421-100ul 100ul
EUR 210
Description: WB,ELISA(peptide)

Phospho-IRS1 (Ser1101) Antibody
AF4421-200ul 200ul
EUR 270
Description: WB,ELISA(peptide)

Phospho-IRS1 (Ser1101) Antibody
MBS9613222-005mL 0.05mL
EUR 245

Phospho-IRS1 (Ser1101) Antibody
MBS9613222-01mL 0.1mL
EUR 310

Phospho-IRS1 (Ser1101) Antibody
MBS9613222-02mL 0.2mL
EUR 370

Phospho-IRS1 (Ser1101) Antibody
MBS9613222-5x02mL 5x0.2mL
EUR 1605

Phospho-IRS1 (Ser639) Antibody
CSB-PA004394- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser639) Antibody
CSB-PA004394-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser636) Antibody
CSB-PA577877- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser636) Antibody
CSB-PA577877-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser312) Antibody
CSB-PA174165- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser312) Antibody
CSB-PA174165-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser307) Antibody
CSB-PA224848- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody
CSB-PA224848-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody
AF3272 200ul
EUR 420

Phospho-IRS1 (Ser307) Antibody
AF3272-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser307) Antibody
AF3272-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser312) Antibody
AF3273 200ul
EUR 420

Phospho-IRS1 (Ser312) Antibody
AF3273-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser312) Antibody
AF3273-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser636) Antibody
AF3274 200ul
EUR 420

Phospho-IRS1 (Ser636) Antibody
AF3274-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser636) Antibody
AF3274-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser639) Antibody
AF3275 200ul
EUR 420

Phospho-IRS1 (Ser639) Antibody
AF3275-100ul 100ul
EUR 168
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser639) Antibody
AF3275-200ul 200ul
EUR 210
Description: WB,IHC,IF/ICC,ELISA(peptide)

Phospho-IRS1 (Ser312) Antibody
MBS7132913-01mL 0.1mL
EUR 310

Phospho-IRS1 (Ser312) Antibody
MBS7132913-5x01mL 5x0.1mL
EUR 1395

Phospho-IRS1 (Ser307) Antibody
MBS7132938-01mL 0.1mL
EUR 310

Phospho-IRS1 (Ser307) Antibody
MBS7132938-5x01mL 5x0.1mL
EUR 1395

Phospho-IRS1 (Ser636) Antibody
MBS7133325-01mL 0.1mL
EUR 310

Phospho-IRS1 (Ser636) Antibody
MBS7133325-5x01mL 5x0.1mL
EUR 1395

Phospho-IRS1 (Ser639) Antibody
MBS7133326-01mL 0.1mL
EUR 310

Phospho-IRS1 (Ser639) Antibody
MBS7133326-5x01mL 5x0.1mL
EUR 1395

IRS2 (Phospho- Ser1100) Antibody
ABF8383 100 ug
EUR 525.6

Phospho-IRS (Ser616) Antibody (Clone HIR-B1)
3105-100 each
EUR 430.8

Phospho-IRS1 (Ser318)[Ser323] Antibody
AF4422 200ul
EUR 540

Phospho-IRS1 (Ser318)[Ser323] Antibody
AF4422-100ul 100ul
EUR 210
Description: WB,ELISA(peptide)

Phospho-IRS1 (Ser318)[Ser323] Antibody
AF4422-200ul 200ul
EUR 270
Description: WB,ELISA(peptide)

Phospho-IRS1 (Ser318)[Ser323] Antibody
MBS9613223-005mL 0.05mL
EUR 245

Phospho-IRS1 (Ser318)[Ser323] Antibody
MBS9613223-01mL 0.1mL
EUR 310

Phospho-IRS1 (Ser318)[Ser323] Antibody
MBS9613223-02mL 0.2mL
EUR 370

Phospho-IRS1 (Ser318)[Ser323] Antibody
MBS9613223-5x02mL 5x0.2mL
EUR 1605

Phospho-IRS1 (Ser636) Polyclonal Antibody
E-AB-20908-120uL 120uL
EUR 240
Description: Unconjugated

Phospho-IRS1 (Ser636) Polyclonal Antibody
E-AB-20908-200uL 200uL
EUR 399
Description: Unconjugated

Phospho-IRS1 (Ser636) Polyclonal Antibody
E-AB-20908-20uL 20uL
EUR 73
Description: Unconjugated

Phospho-IRS1 (Ser636) Polyclonal Antibody
E-AB-20908-60uL 60uL
EUR 143
Description: Unconjugated

Phospho-IRS1 (Ser636) polyclonal antibody
BZ16044 50ul
EUR 398
Description: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Phospho-IRS1 (Ser639) polyclonal antibody
BZ16409 50ul
EUR 398
Description: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Phospho-IRS1 (Ser636) Polyclonal Antibody
RD85874A-120uL 120μL
EUR 360
Description: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Phospho-IRS1 (Ser636) Polyclonal Antibody
RD85874A-200uL 200μL
EUR 630
Description: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Phospho-IRS1 (Ser636) Polyclonal Antibody
RD85874A-20uL 20μL
EUR 109.5
Description: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

Phospho-IRS1 (Ser636) Polyclonal Antibody
RD85874A-60uL 60μL
EUR 214.5
Description: May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit.

IRS-1 (phospho Ser1101) Polyclonal Antibody
ABP50340-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser1101) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser1101) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S1101

IRS-1 (phospho Ser1101) Polyclonal Antibody
ABP50340-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser1101) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser1101) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S1101

IRS-1 (phospho Ser1101) Polyclonal Antibody
ABP50340-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser1101) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser1101) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S1101

IRS-1 (phospho Ser1101) Polyclonal Antibody
E013783 100μg/100μl
EUR 255
Description: Available in various conjugation types.

IRS-1(Phospho Ser1101) Polyclonal Antibody
BT-AP10507-100ul 100ul Ask for price
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

IRS-1(Phospho Ser1101) Polyclonal Antibody
BT-AP10507-20ul 20ul Ask for price
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

IRS-1(Phospho Ser1101) Polyclonal Antibody
BT-AP10507-50ul 50ul Ask for price
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

IRS-1(Phospho Ser1101) Polyclonal Antibody
JOT-AP10507-100ul 100ul
EUR 220

IRS-1(Phospho Ser1101) Polyclonal Antibody
JOT-AP10507-50ul 50ul
EUR 144

IRS-1 (phospho Ser1101) Polyclonal Antibody
E20-60145 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser1101) Polyclonal Antibody
E44H00813 100ul
EUR 255
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

IRS-1 (phospho Ser1101) Polyclonal Antibody
MBS8519919-01mg 0.1mg
EUR 305

IRS-1 (phospho Ser1101) Polyclonal Antibody
MBS8519919-01mLAF405L 0.1mL(AF405L)
EUR 465

IRS-1 (phospho Ser1101) Polyclonal Antibody
MBS8519919-01mLAF405S 0.1mL(AF405S)
EUR 465

IRS-1 (phospho Ser1101) Polyclonal Antibody
MBS8519919-01mLAF610 0.1mL(AF610)
EUR 465

IRS-1 (phospho Ser1101) Polyclonal Antibody
MBS8519919-01mLAF635 0.1mL(AF635)
EUR 465

IRS-1 (phospho Ser1101) Polyclonal Antibody
MBS9242007-01mL 0.1mL
EUR 425

IRS-1 (phospho Ser1101) Polyclonal Antibody
MBS9242007-5x01mL 5x0.1mL
EUR 1887

IRS-1 (phospho Ser1101) Polyclonal Antibody
UB-GEN-3444 100 ul
EUR 200

IRS-1 (phospho Ser323) Polyclonal Antibody
ABP54929-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser323) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser323) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S323

IRS-1 (phospho Ser323) Polyclonal Antibody
ABP54929-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser323) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser323) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S323

IRS-1 (phospho Ser323) Polyclonal Antibody
ABP54929-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser323) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser323) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S323

IRS-1 (phospho Ser307) Polyclonal Antibody
ABP50341-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser307) Polyclonal Antibody
ABP50341-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser307) Polyclonal Antibody
ABP50341-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307
A 5′-deletion study showed that the promoter can be truncated to 600 bp long relative to the translation start site without affecting expression. A positive regulatory element was identified between 600 and 481 bp that controls expression in the inner integument, with no noticeable effect on expression in the outer integument or tapetum. Additionally, removal of the 5’UTR intron had no effect on levels or location of gm-hir1 expression while truncation to 370 bp resulted in a complete loss of expression suggesting that elements controlling both the outer integument and tapetum expression are located within the 481-370 bp region.

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