The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.

Inadequate tissue oxygen, or hypoxia, is a central concept in the pathophysiology of ischemic disorders and cancer. Hypoxia promotes extracellular matrix (ECM) remodeling, cellular metabolic adaptation, and cancer cell metastasis. To discover new pathways through which cells respond to hypoxia, we performed a large-scale forward genetic screen in Caenorhabditis elegans and identified a previously uncharacterized receptor tyrosine kinase named HIR-1.
Loss of function in hir-1 phenocopied the impaired ECM integrity associated with hypoxia or deficiency in the oxygen-dependent dual oxidase, heme peroxidases, or cuticular collagens involved in ECM homeostasis. Genetic suppressor screens identified NHR-49 and MDT-15 as transcriptional regulators downstream of HIR-1.
Furthermore, hir-1 mutants showed defects in adapting to and recovering from prolonged severe hypoxia. We propose that C. elegans HIR-1 coordinates hypoxia-inducible factor-independent responses to hypoxia and hypoxia-associated ECM remodeling through mechanisms that are likely conserved in other organisms.

The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals.

Morphological plasticity such as the yeast-to-hyphae transition is a key virulence factor of the human fungal pathogen Candida albicans. Hyphal formation is controlled by a multilayer regulatory network composed of environmental sensing, signaling, transcriptional modulators as well as chromatin modifications. Here, we demonstrate a novel role for the replication-independent HIR histone chaperone complex in fungal morphogenesis. HIR operates as a crucial modulator of hyphal development, since genetic ablation of the HIR complex subunit Hir1 decreases sensitivity to morphogenetic stimuli.
 The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.
Strikingly, HIR1-deficient cells display altered transcriptional amplitudes upon hyphal initiation, suggesting that Hir1 affects transcription by establishing transcriptional thresholds required for driving morphogenetic cell-fate decisions. Furthermore, ectopic expression of the transcription factor Ume6, which facilitates hyphal maintenance, rescues filamentation defects of hir1Δ/Δ cells, suggesting that Hir1 impacts the early phase of hyphal initiation. Hence, chromatin chaperone-mediated fine-tuning of transcription is crucial for driving morphogenetic conversions in the fungal pathogen C. albicans.

The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast.

In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by homologous recombination takes place in a nucleosomal environment. Nucleosomes may represent an obstacle for the recombination machinery and their timely eviction and reincorporation into chromatin may influence the outcome of recombination, for instance by stabilizing recombination intermediates.
Here we show in budding yeast that nucleosomes flanking a meiotic DSB are transiently lost during recombination, and that specific histone H3 chaperones, CAF-1 and Hir, are mobilized at meiotic DSBs. However, the absence of these chaperones has no effect on meiotic recombination, suggesting that timely histone reincorporation following their eviction has no influence on the recombination outcome, or that redundant pathways are activated. This study is the first example of the involvement of histone H3 chaperones at naturally occurring, developmentally programmed DNA double-strand breaks.

The histone chaperone complex HIR maintains nucleosome occupancy and counterbalances impaired histone deposition in CAF-1 complex mutants.

Chromatin organization is essential for coordinated gene expression, genome stability, and inheritance of epigenetic information. The main components involved in chromatin assembly are specific complexes such as Chromatin Assembly Factor 1 (CAF-1) and Histone Regulator (HIR), which deposit histones in a DNA synthesis-dependent or -independent manner, respectively. Here, we characterize the role of the plant orthologs Histone Regulator A (HIRA), Ubinuclein (UBN) and Calcineurin Binding protein 1 (CABIN1), which constitute the HIR complex.
Arabidopsis loss-of-function mutants for the various subunits of the complex are viable, but hira mutants show reduced fertility. We show that loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions. Concomitantly, HIRA contributes to maintenance of silencing of pericentromeric repeats and certain transposons.
A genetic analysis based on crosses between mutants deficient in subunits of the CAF-1 and HIR complexes showed that simultaneous loss of both the CAF-1 and HIR histone H3 chaperone complexes severely affects plant survival, growth and reproductive development. Our results suggest that HIRA partially rescues impaired histone deposition in fas mutants to preserve nucleosome occupancy, implying plasticity in histone variant interaction and deposition.

Tissue-specific expression of a soybean hypersensitive-induced response (HIR) protein gene promoter.

A Glycine max gene encoding a putative protein similar to hypersensitive-induced response proteins (HIR) was identified as a gene with preferred expressions in flowers and developing seeds by whole transcriptome gene expression profiling. Its promoter gm-hir1 was cloned and revealed to strongly express a fluorescence reporter gene primarily in integuments, anther tapetum, and seed coat with unique tissue-specificity. Expression in the inner integument was apparent prior to pollination, while expression in the outer integument started to develop from the micropylar end outward as the embryo matured.

Phospho-DRP1 (Ser616) Antibody

DF2972 200ul
EUR 420

Kv4.2/KCND2 (Phospho-Ser616) Antibody

12447-100ul 100ul
EUR 302.4

Kv4.2/KCND2 (Phospho-Ser616) Antibody

12447-50ul 50ul
EUR 224.4

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2/KCND2 (Phospho- Ser616) Antibody

ABF8074 100 ug
EUR 525.6

Phospho-Kv4.2/KCND2 (Ser616) Antibody

AF8074 200ul
EUR 540

Kv4.2 (phospho Ser616) Polyclonal Antibody

ES5998-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Kv4.2 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Kv4.2 (phospho Ser616) Polyclonal Antibody

ES5998-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Kv4.2 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

IRS-1 (phospho Ser616) Polyclonal Antibody

ABP54928-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

IRS-1 (phospho Ser616) Polyclonal Antibody

ABP54928-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

IRS-1 (phospho Ser616) Polyclonal Antibody

ABP54928-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser616) from Human, Mouse, Rat. This IRS-1 phospho Ser616) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S616

DRP1 (Phospho-Ser616) Polyclonal Conjugated Antibody

C12749 100ul
EUR 476.4

IRS-1 (phospho Ser616) Polyclonal Antibody

ES5927-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser616) Polyclonal Antibody

ES5927-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Phospho-IRS1 (S1101) Antibody

1-CSB-PA000553
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S1101). Recognizes Phospho-IRS1 (S1101) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

Phospho-IRS1 (S307) Antibody

1-CSB-PA000554
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S307). Recognizes Phospho-IRS1 (S307) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-IRS1 (S307) Antibody

1-CSB-PA000555
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S307). Recognizes Phospho-IRS1 (S307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

Phospho-IRS1 (S636) Antibody

1-CSB-PA000556
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S636). Recognizes Phospho-IRS1 (S636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

Phospho-IRS1 (S639) Antibody

1-CSB-PA000557
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S639). Recognizes Phospho-IRS1 (S639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

Phospho-IRS1 (S794) Antibody

1-CSB-PA000558
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S794). Recognizes Phospho-IRS1 (S794) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/40000

Phospho-IRS1 (S312) Antibody

1-CSB-PA000667
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S312). Recognizes Phospho-IRS1 (S312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IF, ELISA;WB:1/500-1/2000.IF:1/200-1/1000.ELISA:1/20000

Phospho-IRS1 (Ser636) Antibody

CSB-PA577877-
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser636) Antibody

CSB-PA577877-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody

AF3272 200ul
EUR 420

Phospho-IRS1 (Ser312) Antibody

AF3273 200ul
EUR 420

Phospho-IRS1 (Ser636) Antibody

AF3274 200ul
EUR 420

Phospho-IRS1 (Ser639) Antibody

AF3275 200ul
EUR 420

Phospho-IRS1 (Tyr612) Antibody

AF3677 100ul
EUR 540

Phospho-IRS1 (Tyr989) Antibody

AF3807 100ul
EUR 540

Phospho-IRS1 (Ser1101) Antibody

AF4421 200ul
EUR 540

Phospho-IRS1 (Tyr896) Antibody

AF4424 200ul
EUR 540

Phospho-IRS1 (Ser312) Antibody

CSB-PA174165-
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser312) Antibody

CSB-PA174165-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser307) Antibody

CSB-PA224848-
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody

CSB-PA224848-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Ser639) Antibody

CSB-PA004394-
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser639) Antibody

CSB-PA004394-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Y896) Antibody

1-CSB-PA011243
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (Y896). Recognizes Phospho-IRS1 (Y896) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/40000

Phospho-IRS1 (S616) Antibody

1-CSB-PA011244
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S616). Recognizes Phospho-IRS1 (S616) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

Phospho-IRS1 (S323) Antibody

1-CSB-PA011245
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against Phospho-IRS1 (S323). Recognizes Phospho-IRS1 (S323) from Human, Mouse, Rat, Monkey. This antibody is Unconjugated. Tested in the following application: WB, IHC, IF, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/10000

Phospho-DRP1 (Ser616) Blocking Peptide

AF8470-BP 1mg
EUR 234

Phospho-DRP1 (Ser616) Blocking Peptide

DF2972-BP 1mg
EUR 234

Phospho-IRS (Ser616) Antibody (Clone HIR-B1)

3105-100
EUR 430.8

Kv4.2/KCND2 (Phospho-Ser616) Polyclonal Conjugated Antibody

C12447 100ul
EUR 476.4

Phospho-IRS1 (Ser318)[Ser323] Antibody

AF4422 200ul
EUR 540

Anti-Phospho-IRS1-S1101 antibody

STJ11101007 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-S323 antibody

STJ11101089 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S307) antibody

STJ110879 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S312) antibody

STJ22196 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S636) antibody

STJ22197 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S639) antibody

STJ22198 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Anti-Phospho-IRS1-(S307) antibody

STJ22199 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Phospho-Kv4.2/KCND2 (Ser616) Blocking Peptide

AF8074-BP 1mg
EUR 234

Phospho-IRS-1 (Ser616) Blocking Peptide

AF4423-BP 1mg
EUR 234

KCND2 antibody (Ser616)

70R-35925 100 ug
EUR 392.4
Description: Rabbit polyclonal KCND2 antibody (Ser616)

anti-IRS1 (Phospho-Ser612)

LF-PA20649 100 ul
EUR 424.8
Description: Rabbit polyclonal to IRS1 (Phospho-Ser612)

Dynamin-1-Like Protein Phospho-Ser616 (DRP1) Antibody

20-abx149897
  • EUR 526.80
  • EUR 109.20
  • 100 ug
  • 10 ug

Anti-Phospho-IRS1-S636/639 antibody

STJ11101023 100 µl
EUR 471.6
Description: This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Hu-48T 48T
EUR 620.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Hu-96T 96T
EUR 807.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Mu-48T 48T
EUR 632.4
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Mu-96T 96T
EUR 825.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Ra-48T 48T
EUR 658.8
Description: A sandwich quantitative ELISA assay kit for detection of Rat Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

DLR-IRS1-Ra-96T 96T
EUR 861.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Insulin Receptor Substrate 1 (IRS1) in samples from tissue homogenates, cell lysates or other biological fluids.

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Hu-48Tests 48 Tests
EUR 652.8

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Hu-96Tests 96 Tests
EUR 907.2

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Mu-48Tests 48 Tests
EUR 668.4

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Mu-96Tests 96 Tests
EUR 928.8

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Ra-48Tests 48 Tests
EUR 699.6

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RDR-IRS1-Ra-96Tests 96 Tests
EUR 973.2

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Hu-48Tests 48 Tests
EUR 625.2

Human Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Hu-96Tests 96 Tests
EUR 867.6

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Mu-48Tests 48 Tests
EUR 639.6

Mouse Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Mu-96Tests 96 Tests
EUR 888

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Ra-48Tests 48 Tests
EUR 668.4

Rat Insulin Receptor Substrate 1 (IRS1) ELISA Kit

RD-IRS1-Ra-96Tests 96 Tests
EUR 930

Phospho-IRS1-S312 Rabbit pAb

AP0181-100ul 100 ul
EUR 460.8

Phospho-IRS1-S312 Rabbit pAb

AP0181-200ul 200 ul
EUR 664.8

Phospho-IRS1-S312 Rabbit pAb

AP0181-20ul 20 ul Ask for price

Phospho-IRS1-S312 Rabbit pAb

AP0181-50ul 50 ul
EUR 318

Phospho-IRS1-S636 Rabbit pAb

AP0225-100ul 100 ul
EUR 460.8

Phospho-IRS1-S636 Rabbit pAb

AP0225-200ul 200 ul
EUR 664.8

Phospho-IRS1-S636 Rabbit pAb

AP0225-20ul 20 ul Ask for price

Phospho-IRS1-S636 Rabbit pAb

AP0225-50ul 50 ul
EUR 318

Phospho-IRS1-S639 Rabbit pAb

AP0226-100ul 100 ul
EUR 460.8

Phospho-IRS1-S639 Rabbit pAb

AP0226-200ul 200 ul
EUR 664.8

Phospho-IRS1-S639 Rabbit pAb

AP0226-20ul 20 ul Ask for price

Phospho-IRS1-S639 Rabbit pAb

AP0226-50ul 50 ul
EUR 318

Phospho-IRS1-S307 Rabbit pAb

AP0371-100ul 100 ul
EUR 460.8

Phospho-IRS1-S307 Rabbit pAb

AP0371-200ul 200 ul
EUR 664.8

Phospho-IRS1-S307 Rabbit pAb

AP0371-20ul 20 ul Ask for price

Phospho-IRS1-S307 Rabbit pAb

AP0371-50ul 50 ul
EUR 318

Phospho-IRS1-S307 Rabbit pAb

AP0552-100ul 100 ul
EUR 460.8

Phospho-IRS1-S307 Rabbit pAb

AP0552-200ul 200 ul
EUR 664.8

Phospho-IRS1-S307 Rabbit pAb

AP0552-20ul 20 ul
EUR 219.6

Phospho-IRS1-S307 Rabbit pAb

AP0552-50ul 50 ul
EUR 318

Phospho-IRS1-S1101 Rabbit pAb

AP0867-100ul 100 ul
EUR 460.8

Phospho-IRS1-S1101 Rabbit pAb

AP0867-200ul 200 ul
EUR 664.8

Phospho-IRS1-S1101 Rabbit pAb

AP0867-20ul 20 ul
EUR 219.6

Phospho-IRS1-S1101 Rabbit pAb

AP0867-50ul 50 ul
EUR 318

Phospho-IRS1-S323 Rabbit pAb

AP0966-100ul 100 ul
EUR 460.8

Phospho-IRS1-S323 Rabbit pAb

AP0966-200ul 200 ul
EUR 664.8

Phospho-IRS1-S323 Rabbit pAb

AP0966-20ul 20 ul
EUR 219.6

Phospho-IRS1-S323 Rabbit pAb

AP0966-50ul 50 ul
EUR 318

IRS1 antibody

70R-11816 100 ug
EUR 483.6
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-37602 100 ug
EUR 327.6
Description: Rabbit Polyclonal IRS1 antibody

IRS1 antibody

70R-49927 100 ul
EUR 344.4
Description: Purified Polyclonal IRS1 antibody

IRS1 antibody

70R-49928 100 ul
EUR 344.4
Description: Purified Polyclonal IRS1 antibody

IRS1 antibody

70R-49929 100 ul
EUR 292.8
Description: Purified Polyclonal IRS1 antibody

IRS1 antibody

70R-34209 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-34211 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-34213 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-34215 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-35306 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-36824 100 ug
EUR 392.4
Description: Rabbit Polyclonal IRS1 antibody

IRS1 antibody

70R-18013 50 ul
EUR 522
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-31319 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

70R-31321 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

38112-100ul 100ul
EUR 302.4

IRS1 Antibody

49156-100ul 100ul
EUR 399.6

IRS1 Antibody

49156-50ul 50ul
EUR 286.8

IRS1 Antibody

35792-100ul 100ul
EUR 302.4

IRS1 antibody

20R-1996 50 ug
EUR 337.2
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

20R-2070 50 ug
EUR 337.2
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

20R-2071 50 ug
EUR 337.2
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

20R-2386 50 ug
EUR 337.2
Description: Rabbit polyclonal IRS1 antibody

IRS1 antibody

20R-2387 50 ug
EUR 337.2
Description: Rabbit polyclonal IRS1 antibody

IRS1 Antibody

ABD6048 100 ug
EUR 525.6

IRS1 Antibody

AF6807 100ul
EUR 420

IRS1 Antibody

DF6048 200ul
EUR 420

IRS1 Antibody

AF4721 200ul
EUR 540

IRS1 Antibody

AF4722 200ul
EUR 540

IRS1 Antibody

AF4723 200ul
EUR 540

IRS1 Antibody

AF4724 200ul
EUR 540

IRS1 Antibody

AF6272 200ul
EUR 420

IRS1 Antibody

AF6273 200ul
EUR 420

IRS1 Antibody

AF6677 100ul
EUR 420

IRS1 Antibody

1-CSB-PA218932
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:50-1:200

IRS1 Antibody

1-CSB-PA230288
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:25-1:100

IRS1 Antibody

1-CSB-PA011247
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/5000

IRS1 Antibody

1-CSB-PA011248
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/5000

IRS1 Antibody

1-CSB-PA011249
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

IRS1 Antibody

1-CSB-PA011250
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/5000

IRS1 Antibody

1-CSB-PA011829DSR1HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

IRS1 Antibody

1-CSB-PA011829GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

IRS1 Antibody

1-CSB-PA003065
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/5000

IRS1 Antibody

1-CSB-PA003068
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against IRS1. Recognizes IRS1 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: WB, IHC, ELISA;WB:1/500-1/2000.IHC:1/100-1/300.ELISA:1/20000

IRS1 Antibody

R31636 100 ug
EUR 419

IRS1 Antibody

RQ5507 100 ug
EUR 419

Phospho-IRS1-S636/639 Rabbit pAb

AP0885-100ul 100 ul
EUR 460.8

Phospho-IRS1-S636/639 Rabbit pAb

AP0885-200ul 200 ul
EUR 664.8

Phospho-IRS1-S636/639 Rabbit pAb

AP0885-20ul 20 ul
EUR 219.6

Phospho-IRS1-S636/639 Rabbit pAb

AP0885-50ul 50 ul
EUR 318

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser312

CPB-1258RH 100 ul
EUR 670.8

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser636

CPB-768RH 100 ul
EUR 670.8

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser639

CPB-769RH 100 ul
EUR 670.8

Monoclonal Phospho-IRS (Ser616) Antibody (Clone HIR-B1), Clone: HIR-B1

APR09169G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human Phospho-IRS (Ser616) (Clone HIR-B1). The antibodies are raised in Mouse and are from clone HIR-B1. This antibody is applicable in WB, E

IRS1 antibody (Ser636)

70R-37296 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser636)

IRS1 antibody (Ser639)

70R-37297 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser639)

IRS1 antibody (Ser307)

70R-37301 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser307)

IRS1 antibody (Ser612)

70R-37439 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser612)

IRS1 antibody (Ser307)

70R-34208 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser307)

IRS1 antibody (Ser312)

70R-34210 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser312)

IRS1 antibody (Ser636)

70R-34212 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser636)

IRS1 antibody (Ser639)

70R-34214 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser639)

IRS1 antibody (Ser794)

70R-35835 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser794)

IRS1 antibody (Ser323)

70R-35928 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser323)

IRS1 antibody (Ser312)

70R-37221 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser312)

IRS1 antibody (Ser307)

70R-31072 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser307)

IRS1 antibody (Ser1101)

70R-31318 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser1101)

IRS1 antibody (Ser612)

70R-31320 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser612)

IRS1 (pS307) Antibody

20-abx133119
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

IRS1 (pS794) Antibody

20-abx133193
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul

IRS1 (pS312) Antibody

20-abx133596
  • EUR 376.80
  • EUR 560.40
  • EUR 243.60
  • 100 ul
  • 200 ul
  • 30 ul
A 5′-deletion study showed that the promoter can be truncated to 600 bp long relative to the translation start site without affecting expression. A positive regulatory element was identified between 600 and 481 bp that controls expression in the inner integument, with no noticeable effect on expression in the outer integument or tapetum. Additionally, removal of the 5’UTR intron had no effect on levels or location of gm-hir1 expression while truncation to 370 bp resulted in a complete loss of expression suggesting that elements controlling both the outer integument and tapetum expression are located within the 481-370 bp region.

Leave a Reply

Your email address will not be published.