The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.

Inadequate tissue oxygen, or hypoxia, is a central concept in the pathophysiology of ischemic disorders and cancer. Hypoxia promotes extracellular matrix (ECM) remodeling, cellular metabolic adaptation, and cancer cell metastasis. To discover new pathways through which cells respond to hypoxia, we performed a large-scale forward genetic screen in Caenorhabditis elegans and identified a previously uncharacterized receptor tyrosine kinase named HIR-1.
Loss of function in hir-1 phenocopied the impaired ECM integrity associated with hypoxia or deficiency in the oxygen-dependent dual oxidase, heme peroxidases, or cuticular collagens involved in ECM homeostasis. Genetic suppressor screens identified NHR-49 and MDT-15 as transcriptional regulators downstream of HIR-1.
Furthermore, hir-1 mutants showed defects in adapting to and recovering from prolonged severe hypoxia. We propose that C. elegans HIR-1 coordinates hypoxia-inducible factor-independent responses to hypoxia and hypoxia-associated ECM remodeling through mechanisms that are likely conserved in other organisms.

The Candida albicans HIR histone chaperone regulates the yeast-to-hyphae transition by controlling the sensitivity to morphogenesis signals.

Morphological plasticity such as the yeast-to-hyphae transition is a key virulence factor of the human fungal pathogen Candida albicans. Hyphal formation is controlled by a multilayer regulatory network composed of environmental sensing, signaling, transcriptional modulators as well as chromatin modifications. Here, we demonstrate a novel role for the replication-independent HIR histone chaperone complex in fungal morphogenesis. HIR operates as a crucial modulator of hyphal development, since genetic ablation of the HIR complex subunit Hir1 decreases sensitivity to morphogenetic stimuli.
 The receptor tyrosine kinase HIR-1 coordinates HIF-independent responses to hypoxia and extracellular matrix injury.
Strikingly, HIR1-deficient cells display altered transcriptional amplitudes upon hyphal initiation, suggesting that Hir1 affects transcription by establishing transcriptional thresholds required for driving morphogenetic cell-fate decisions. Furthermore, ectopic expression of the transcription factor Ume6, which facilitates hyphal maintenance, rescues filamentation defects of hir1Δ/Δ cells, suggesting that Hir1 impacts the early phase of hyphal initiation. Hence, chromatin chaperone-mediated fine-tuning of transcription is crucial for driving morphogenetic conversions in the fungal pathogen C. albicans.

The CAF-1 and Hir Histone Chaperones Associate with Sites of Meiotic Double-Strand Breaks in Budding Yeast.

In the meiotic prophase, programmed DNA double-strand breaks (DSB) are introduced along chromosomes to promote homolog pairing and recombination. Although meiotic DSBs usually occur in nucleosome-depleted, accessible regions of chromatin, their repair by homologous recombination takes place in a nucleosomal environment. Nucleosomes may represent an obstacle for the recombination machinery and their timely eviction and reincorporation into chromatin may influence the outcome of recombination, for instance by stabilizing recombination intermediates.
Here we show in budding yeast that nucleosomes flanking a meiotic DSB are transiently lost during recombination, and that specific histone H3 chaperones, CAF-1 and Hir, are mobilized at meiotic DSBs. However, the absence of these chaperones has no effect on meiotic recombination, suggesting that timely histone reincorporation following their eviction has no influence on the recombination outcome, or that redundant pathways are activated. This study is the first example of the involvement of histone H3 chaperones at naturally occurring, developmentally programmed DNA double-strand breaks.

The histone chaperone complex HIR maintains nucleosome occupancy and counterbalances impaired histone deposition in CAF-1 complex mutants.

Chromatin organization is essential for coordinated gene expression, genome stability, and inheritance of epigenetic information. The main components involved in chromatin assembly are specific complexes such as Chromatin Assembly Factor 1 (CAF-1) and Histone Regulator (HIR), which deposit histones in a DNA synthesis-dependent or -independent manner, respectively. Here, we characterize the role of the plant orthologs Histone Regulator A (HIRA), Ubinuclein (UBN) and Calcineurin Binding protein 1 (CABIN1), which constitute the HIR complex.
Arabidopsis loss-of-function mutants for the various subunits of the complex are viable, but hira mutants show reduced fertility. We show that loss of HIRA reduces extractable histone H3 protein levels and decreases nucleosome occupancy at both actively transcribed genes and heterochromatic regions. Concomitantly, HIRA contributes to maintenance of silencing of pericentromeric repeats and certain transposons.
A genetic analysis based on crosses between mutants deficient in subunits of the CAF-1 and HIR complexes showed that simultaneous loss of both the CAF-1 and HIR histone H3 chaperone complexes severely affects plant survival, growth and reproductive development. Our results suggest that HIRA partially rescues impaired histone deposition in fas mutants to preserve nucleosome occupancy, implying plasticity in histone variant interaction and deposition.

Tissue-specific expression of a soybean hypersensitive-induced response (HIR) protein gene promoter.

A Glycine max gene encoding a putative protein similar to hypersensitive-induced response proteins (HIR) was identified as a gene with preferred expressions in flowers and developing seeds by whole transcriptome gene expression profiling. Its promoter gm-hir1 was cloned and revealed to strongly express a fluorescence reporter gene primarily in integuments, anther tapetum, and seed coat with unique tissue-specificity. Expression in the inner integument was apparent prior to pollination, while expression in the outer integument started to develop from the micropylar end outward as the embryo matured.

IRS-1 (phospho Ser616) Polyclonal Antibody

E013782 100μg/100μl
EUR 255
Description: Available in various conjugation types.

IRS-1 (phospho Ser616) Polyclonal Antibody

E20-60640 100ug
EUR 225
Description: Available in various conjugation types.

DRP1 (Phospho- Ser616) Antibody

ABF8470 100 ug
EUR 525.6

Phospho- DRP1 (Ser616) Antibody

ABD2972 100 ug
EUR 525.6

Phospho- DRP1 (Ser616) Antibody

ABD2981 100 ug
EUR 525.6

Phospho-DRP1 (Ser616) Antibody

DF2972 200ul
EUR 420

Phospho-DRP1 (Ser616) Antibody

AF8470 100ul
EUR 350
Description: Human,Mouse,Rat

Phospho-DRP1 (Ser616) Antibody

AF8470-100ul 100ul
EUR 350

Phospho-DRP1 (Ser616) Antibody

AF8470-200ul 200ul
EUR 450

Phospho-DRP1 (Ser616) Antibody

E19-2972-1 50ug/50ul
EUR 145
Description: Available in various conjugation types.

Phospho-DRP1 (Ser616) Antibody

E19-2972-2 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Kv4.2/KCND2 (Phospho- Ser616) Antibody

ABF8074 100 ug
EUR 525.6

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody

ABP54999-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of Kv4.2 phospho Ser616) from Human, Mouse, Rat. This Kv4.2 phospho Ser616) antibody is for IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human Kv4.2 around the phosphorylation site of S616

Kv4.2 (phospho Ser616) Polyclonal Antibody

ES5998-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against Kv4.2 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Kv4.2 (phospho Ser616) Polyclonal Antibody

ES5998-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against Kv4.2 (phospho Ser616) from Human/Mouse/Rat. This antibody is tested and validated for IHC, WB, ELISA

Kv4.2 (phospho Ser616) Polyclonal Antibody

E013756 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Kv4.2 (phospho Ser616) Polyclonal Antibody

E20-61005 100ug
EUR 225
Description: Available in various conjugation types.

Phospho-IRS-1 (Ser616) Antibody

E11-184423 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Phospho-Kv4.2/KCND2 (Ser616) Antibody

AF8074 100ul
EUR 350
Description: Human,Mouse,Rat

Phospho-Kv4.2/KCND2 (Ser616) Antibody

AF8074-100ul 100ul
EUR 350

Phospho-Kv4.2/KCND2 (Ser616) Antibody

AF8074-200ul 200ul
EUR 450

Insulin Receptor Substrate 1 Phospho-Ser616 (IRS1 pS616) Antibody

20-abx329007
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

IRS2 (Phospho- Ser1100) Antibody

ABF8383 100 ug
EUR 525.6

Phospho-IRS1 (Ser1101) Antibody

AF4421 100ul
EUR 350
Description: Human,Mouse,Rat

Phospho-IRS1 (Ser1101) Antibody

AF4421-100ul 100ul
EUR 350

Phospho-IRS1 (Ser1101) Antibody

AF4421-200ul 200ul
EUR 450

Phospho-IRS1 (Ser312) Antibody

CSB-PA174165- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser312) Antibody

CSB-PA174165-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser312). Recognizes Phospho-IRS1 (Ser312) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB;WB:1:500-1:1000

Phospho-IRS1 (Ser639) Antibody

CSB-PA004394- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser639) Antibody

CSB-PA004394-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser639). Recognizes Phospho-IRS1 (Ser639) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody

CSB-PA224848- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody

CSB-PA224848-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser307). Recognizes Phospho-IRS1 (Ser307) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;IHC:1:50-1:100

Phospho-IRS1 (Ser636) Antibody

CSB-PA577877- each
EUR 402
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser636) Antibody

CSB-PA577877-100ul 100ul
EUR 434.4
Description: A polyclonal antibody against Phospho-IRS1 (Ser636). Recognizes Phospho-IRS1 (Ser636) from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC;WB:1:500-1:1000, IHC:1:50-1:100

Phospho-IRS1 (Ser307) Antibody

AF3272 100ul
EUR 280
Description: Human,Mouse,Rat,Monkey

Phospho-IRS1 (Ser312) Antibody

AF3273 100ul
EUR 280
Description: Human,Mouse,Rat,Monkey

Phospho-IRS1 (Ser636) Antibody

AF3274 100ul
EUR 280
Description: Human,Mouse,Rat,Monkey

Phospho-IRS1 (Ser639) Antibody

AF3275 100ul
EUR 280
Description: Human,Mouse,Rat,Monkey

Phospho-IRS1 (Ser307) Antibody

AF3272-100ul 100ul
EUR 280

Phospho-IRS1 (Ser307) Antibody

AF3272-200ul 200ul
EUR 350

Phospho-IRS1 (Ser312) Antibody

AF3273-100ul 100ul
EUR 280

Phospho-IRS1 (Ser312) Antibody

AF3273-200ul 200ul
EUR 350

Phospho-IRS1 (Ser636) Antibody

AF3274-100ul 100ul
EUR 280

Phospho-IRS1 (Ser636) Antibody

AF3274-200ul 200ul
EUR 350

Phospho-IRS1 (Ser639) Antibody

AF3275-100ul 100ul
EUR 280

Phospho-IRS1 (Ser639) Antibody

AF3275-200ul 200ul
EUR 350

Phospho-IRS1 (Ser318)[Ser323] Antibody

AF4422 100ul
EUR 350
Description: Human,Mouse,Rat

Phospho-IRS1 (Ser318)[Ser323] Antibody

AF4422-100ul 100ul
EUR 350

Phospho-IRS1 (Ser318)[Ser323] Antibody

AF4422-200ul 200ul
EUR 450

Phospho-IRS (Ser616) Antibody (Clone HIR-B1)

3105-100 each
EUR 430.8

IRS-1 (phospho Ser1101) Polyclonal Antibody

ABP50340-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser1101) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser1101) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S1101

IRS-1 (phospho Ser1101) Polyclonal Antibody

ABP50340-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser1101) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser1101) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S1101

IRS-1 (phospho Ser1101) Polyclonal Antibody

ABP50340-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser1101) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser1101) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S1101

IRS-1 (phospho Ser1101) Polyclonal Antibody

ES1339-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser1101) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser1101) Polyclonal Antibody

ES1339-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser1101) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser1101) Polyclonal Antibody

E013783 100μg/100μl
EUR 255
Description: Available in various conjugation types.

IRS-1 (phospho Ser1101) Polyclonal Antibody

E20-60145 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser307) Polyclonal Antibody

ABP50341-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser307) Polyclonal Antibody

ABP50341-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser307) Polyclonal Antibody

ABP50341-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser307) Polyclonal Antibody

ABP50342-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser307) Polyclonal Antibody

ABP50342-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser307) Polyclonal Antibody

ABP50342-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser307) from Human, Mouse, Rat. This IRS-1 phospho Ser307) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S307

IRS-1 (phospho Ser636) Polyclonal Antibody

ABP50343-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser636) from Human, Mouse, Rat. This IRS-1 phospho Ser636) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S636

IRS-1 (phospho Ser636) Polyclonal Antibody

ABP50343-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser636) from Human, Mouse, Rat. This IRS-1 phospho Ser636) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S636

IRS-1 (phospho Ser636) Polyclonal Antibody

ABP50343-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser636) from Human, Mouse, Rat. This IRS-1 phospho Ser636) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S636

IRS-1 (phospho Ser639) Polyclonal Antibody

ABP50344-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser639) from Human, Mouse, Rat. This IRS-1 phospho Ser639) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S639

IRS-1 (phospho Ser639) Polyclonal Antibody

ABP50344-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser639) from Human, Mouse, Rat. This IRS-1 phospho Ser639) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S639

IRS-1 (phospho Ser639) Polyclonal Antibody

ABP50344-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser639) from Human, Mouse, Rat. This IRS-1 phospho Ser639) antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S639

IRS-1 (phospho Ser794) Polyclonal Antibody

ABP50345-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser794) from Human, Mouse, Rat. This IRS-1 phospho Ser794) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S794

IRS-1 (phospho Ser794) Polyclonal Antibody

ABP50345-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser794) from Human, Mouse, Rat. This IRS-1 phospho Ser794) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S794

IRS-1 (phospho Ser794) Polyclonal Antibody

ABP50345-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser794) from Human, Mouse, Rat. This IRS-1 phospho Ser794) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S794

IRS-1 (phospho Ser312) Polyclonal Antibody

ABP50451-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser312) from Human, Mouse, Rat. This IRS-1 phospho Ser312) antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S312

IRS-1 (phospho Ser312) Polyclonal Antibody

ABP50451-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser312) from Human, Mouse, Rat. This IRS-1 phospho Ser312) antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S312

IRS-1 (phospho Ser312) Polyclonal Antibody

ABP50451-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser312) from Human, Mouse, Rat. This IRS-1 phospho Ser312) antibody is for WB , IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S312

IRS-1 (phospho Ser323) Polyclonal Antibody

ABP54929-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of IRS-1 phospho Ser323) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser323) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S323

IRS-1 (phospho Ser323) Polyclonal Antibody

ABP54929-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser323) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser323) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S323

IRS-1 (phospho Ser323) Polyclonal Antibody

ABP54929-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of IRS-1 phospho Ser323) from Human, Mouse, Rat, Monkey. This IRS-1 phospho Ser323) antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human IRS-1 around the phosphorylation site of S323

IRS-1 (phospho Ser307) Polyclonal Antibody

ES1340-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser307) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser307) Polyclonal Antibody

ES1340-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser307) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser307) Polyclonal Antibody

ES1341-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser307) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser307) Polyclonal Antibody

ES1341-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser307) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser636) Polyclonal Antibody

ES1342-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser636) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser636) Polyclonal Antibody

ES1342-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser636) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser639) Polyclonal Antibody

ES1343-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser639) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser639) Polyclonal Antibody

ES1343-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser639) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

IRS-1 (phospho Ser794) Polyclonal Antibody

ES1344-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser794) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser794) Polyclonal Antibody

ES1344-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser794) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser312) Polyclonal Antibody

ES1450-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

IRS-1 (phospho Ser312) Polyclonal Antibody

ES1450-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser312) from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, IF, WB, ELISA

IRS-1 (phospho Ser323) Polyclonal Antibody

ES5928-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser323) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser323) Polyclonal Antibody

ES5928-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against IRS-1 (phospho Ser323) from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

IRS-1 (phospho Ser307) Polyclonal Antibody

E20-60146 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser307) Polyclonal Antibody

E20-60147 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser636) Polyclonal Antibody

E20-60148 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser639) Polyclonal Antibody

E20-60149 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser794) Polyclonal Antibody

E20-60150 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser312) Polyclonal Antibody

E20-60571 100ug
EUR 225
Description: Available in various conjugation types.

IRS-1 (phospho Ser323) Polyclonal Antibody

E20-60881 100ug
EUR 225
Description: Available in various conjugation types.

Phospho- IRS- 1 (Ser1101) Antibody

ABF3622 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser307) Antibody

ABF3272 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser312) Antibody

ABF3273 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser636) Antibody

ABF3274 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser639) Antibody

ABF3275 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser302) Antibody

ABF3623 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser318) Antibody

ABF3624 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser612) Antibody

ABF3625 100 ug
EUR 525.6

Phospho- IRS- 1 (Ser789) Antibody

ABF3626 100 ug
EUR 525.6

IRS1 antibody (Ser1101)

70R-31318 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser1101)

IRS1 antibody (Ser307)

70R-31072 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser307)

IRS1 antibody (Ser612)

70R-31320 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser612)

IRS1 antibody (Ser312)

70R-37221 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser312)

IRS1 antibody (Ser636)

70R-37296 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser636)

IRS1 antibody (Ser639)

70R-37297 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser639)

IRS1 antibody (Ser307)

70R-37301 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser307)

IRS1 antibody (Ser612)

70R-37439 100 ug
EUR 418.8
Description: Rabbit Polyclonal IRS1 antibody (Ser612)

IRS1 antibody (Ser307)

70R-34208 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser307)

IRS1 antibody (Ser312)

70R-34210 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser312)

IRS1 antibody (Ser636)

70R-34212 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser636)

IRS1 antibody (Ser639)

70R-34214 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser639)

IRS1 antibody (Ser794)

70R-35835 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser794)

IRS1 antibody (Ser323)

70R-35928 100 ug
EUR 392.4
Description: Rabbit polyclonal IRS1 antibody (Ser323)

Phospho-DRP1 (Ser616) Blocking Peptide

AF8470-BP 1mg
EUR 234

Phospho-DRP1 (Ser616) Blocking Peptide

DF2972-BP 1mg
EUR 234

Monoclonal Phospho-IRS (Ser616) Antibody (Clone HIR-B1), Clone: HIR-B1

APR09169G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human Phospho-IRS (Ser616) (Clone HIR-B1). The antibodies are raised in Mouse and are from clone HIR-B1. This antibody is applicable in WB, E

Phospho-IRS-1 (Ser616) Blocking Peptide

AF4423-BP 1mg
EUR 234

Phospho-Kv4.2/KCND2 (Ser616) Blocking Peptide

AF8074-BP 1mg
EUR 234

IRS-1 (phospho Ser636) Rabbit pAb

E2251484 100ul
EUR 225
Description: Available in various conjugation types.

Rat Phospho-IRS1 (Ser307) (p-IRS1 Ser307) ELISA kit

YLA1466RA-48T 48T
EUR 465

Rat Phospho-IRS1 (Ser307) (p-IRS1 Ser307) ELISA kit

YLA1466RA-96T 96T
EUR 600

Phospho-IRS1 (Ser639) Rabbit pAb

E2341420 100μl
EUR 225
Description: Available in various conjugation types.

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser636

CPB-768RH 100 ul
EUR 670.8

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser639

CPB-769RH 100 ul
EUR 670.8

Rabbit Anti-Human IRS1 Polyclonal Antibody, Phospho-Ser312

CPB-1258RH 100 ul
EUR 670.8

Rat Phospho-IRS1 (Ser307) ELISA Kit

SL1309Ra -
EUR 498

DRP1 (Phospho-Ser616) Antibody

12749-100ul 100ul
EUR 302.4

DRP1 (Phospho-Ser616) Antibody

12749-50ul 50ul
EUR 224.4

Insulin Receptor Substrate 1 Phospho-Ser307 (IRS1 pS307) Antibody

abx333099-100ul 100 ul
EUR 560.4

Insulin Receptor Substrate 1 Phospho-Ser636 (IRS1 pS636) Antibody

abx333262-100ul 100 ul
EUR 560.4

Insulin Receptor Substrate 1 Phospho-Ser639 (IRS1 pS639) Antibody

abx333263-100ul 100 ul
EUR 560.4

Insulin Receptor Substrate 1 Phospho-Ser312 (IRS1 pS312) Antibody

abx333371-100ul 100 ul
EUR 560.4

Insulin Receptor Substrate 1 Phospho-Ser312 (IRS1 pS312) Antibody

20-abx328087
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Receptor Substrate 1 Phospho-Ser639 (IRS1 pS639) Antibody

20-abx328500
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Receptor Substrate 1 Phospho-Ser307 (IRS1 pS307) Antibody

20-abx329188
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Receptor Substrate 1 Phospho-Ser636 (IRS1 pS636) Antibody

20-abx329323
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Receptor Substrate 1 Phospho-Ser794 (IRS1 pS794) Antibody

20-abx329494
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Receptor Substrate 1 Phospho-Ser307 (IRS1 pS307) Antibody

20-abx330008
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Receptor Substrate 1 Phospho-Ser323 (IRS1 pS323) Antibody

20-abx330033
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Insulin Receptor Substrate 1 Phospho-Ser1101 (IRS1 pS1101) Antibody

20-abx329951
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

ATM (Phospho- Ser1981) Antibody

ABF4120 100 ug
EUR 525.6

ATM (Phospho- Ser1981) Antibody

ABF8225 100 ug
EUR 525.6

ATM (Phospho- Ser1981) Antibody

ABF8409 100 ug
EUR 525.6

ATM (Phospho- Ser1987) Antibody

ABF8410 100 ug
EUR 525.6

Phospho- GR (Ser203) Antibody

ABF0042 100 ug
EUR 525.6

Phospho- GR (Ser211) Antibody

ABF2004 100 ug
EUR 525.6

Phospho- GR (Ser226) Antibody

ABF3066 100 ug
EUR 525.6

Phospho- GR (Ser203) Antibody

ABF3067 100 ug
EUR 525.6

Phospho- Rb (Ser608) Antibody

ABF3726 100 ug
EUR 525.6

Rb (Phospho- Ser795) Antibody

E11-7209A 100μg/100μl
EUR 225
Description: Available in various conjugation types.

eNOS (Phospho- Ser1179) Antibody

ABF8086 100 ug
EUR 525.6

TIE2 (Phospho- Ser1119) Antibody

ABF8193 100 ug
EUR 525.6

CD91 (Phospho- Ser4520) Antibody

ABF8207 100 ug
EUR 525.6

nNOS (Phospho- Ser1417) Antibody

ABF8231 100 ug
EUR 525.6

MUC1 (Phospho- Ser1227) Antibody

ABF8289 100 ug
EUR 525.6

LRP6 (Phospho- Ser1490) Antibody

ABF8344 100 ug
EUR 525.6

TSC2 (Phospho- Ser1254) Antibody

ABF8354 100 ug
EUR 525.6

HSL (Phospho- Ser660) Antibody

ABF8026 100 ug
EUR 525.6

ATM (Phospho- Ser367) Antibody

ABF8099 100 ug
EUR 525.6

ATM (Phospho- Ser183) Antibody

ABF8100 100 ug
EUR 525.6

Met (Phospho- Ser985) Antibody

ABF8121 100 ug
EUR 525.6

KIT (Phospho- Ser746) Antibody

ABF8162 100 ug
EUR 525.6

ZAK (Phospho- Ser165) Antibody

ABF8195 100 ug
EUR 525.6

FAK (Phospho- Ser732) Antibody

ABF8227 100 ug
EUR 525.6

Fos (Phospho- Ser374) Antibody

ABF8270 100 ug
EUR 525.6
A 5′-deletion study showed that the promoter can be truncated to 600 bp long relative to the translation start site without affecting expression. A positive regulatory element was identified between 600 and 481 bp that controls expression in the inner integument, with no noticeable effect on expression in the outer integument or tapetum. Additionally, removal of the 5’UTR intron had no effect on levels or location of gm-hir1 expression while truncation to 370 bp resulted in a complete loss of expression suggesting that elements controlling both the outer integument and tapetum expression are located within the 481-370 bp region.

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