The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.

RNA polymerase II initiates from low complexity sequences so cells must reliably distinguish “real” from “cryptic” promoters and maintain fidelity to the former. Further, this must be performed under a range of conditions, including those found within inactive and highly transcribed regions. Here, we used genome-scale screening to identify those factors that regulate the use of a specific cryptic promoter and how this is influenced by the degree of transcription over the element.
We show that promoter fidelity is most reliant on histone gene transactivators (Spt10, Spt21) and H3-H4 chaperones (Asf1, HIR complex) from the replication-independent deposition pathway. Mutations of Rtt106 that abrogate its interactions with H3-H4 or dsDNA permit extensive cryptic transcription comparable with replication-independent deposition factor deletions. We propose that nucleosome shielding is the primary means to maintain promoter fidelity, and histone replacement is most efficiently mediated in yeast cells by a HIR/Asf1/H3-H4/Rtt106 pathway.

Physical association of Arabidopsis hypersensitive induced reaction proteins (HIRs) with the immune receptor RPS2.

Arabidopsis RPS2 is a typical nucleotide-binding leucine-rich repeat resistance protein, which indirectly recognizes the bacterial effector protein AvrRpt2 and thereby activates effector-triggered immunity (ETI). Previously, we identified two hypersensitive induced reaction (AtHIR) proteins, AtHIR1 (At1g09840) and AtHIR2 (At3g01290), as potential RPS2 complex components.
AtHIR proteins contain the stomatin/prohibitin/flotillin/HflK/C domain (also known as the prohibitin domain or band 7 domain). In this study, we confirmed that AtHIR1 and AtHIR2 form complexes with RPS2 in Arabidopsis and Nicotiana benthamiana using a pulldown assay and fluorescence resonance energy transfer (FRET) analysis.
Arabidopsis has four HIR family genes (AtHIR1-4). All AtHIR proteins could form homo- and hetero-oligomers in vivo and were enriched in membrane microdomains of the plasma membrane. The mRNA levels of all except AtHIR4 were significantly induced by microbe-associated molecular patterns, such as the bacterial flagellin fragment flg22.
Athir2-1 and Athir3-1 mutants allowed more growth of Pto DC3000 AvrRpt2, but not Pto DC3000, indicating that these mutations reduce RPS2-mediated ETI but do not affect basal resistance to the virulent strain. Overexpression of AtHIR1 and AtHIR2 reduced growth of Pto DC3000. Taken together, the results show that the AtHIR proteins are physically associated with RPS2, are localized in membrane microdomains, and quantitatively contribute to RPS2-mediated ETI.

Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes.

The HIR complex, which is comprised of the four proteins Hir1, Hir2, Hir3 and Hpc2, was first characterized as a repressor of three of the four histone gene loci in Saccharomyces cerevisiae. Using a bioinformatical approach, previous studies have identified a region of Hpc2 that is conserved in Schizosaccharomyces pombe and humans. Using a similar approach, we identified two additional domains, CDI and CDII, of the Hpc2 protein that are conserved among yeast species related to S. cerevisiae.
 The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.
We showed that the N terminal CDI domain (spanning amino acids 63-79) is dispensable for HIR complex assembly, but plays an essential role in the repression of the histone genes by recruiting the HIR complex to the HIR-dependent histone gene loci. The second conserved domain, CDII (spanning amino acids 452-480), is required for the stability of the Hpc2 protein itself as well as for the assembly of the HIR complex.
In addition, we report a novel separation-of-function mutation within CDI of Hpc2, which causes derepression of the histone genes but does not confer other reported hir/hpc- phenotypes (such as Spt phenotypes, heterochromatin silencing defects and repression of cryptic promoters). This is the first direct demonstration that a separation-of-function mutation exists within the HIR complex.

The Saccharomyces cerevisiae histone chaperone Rtt106 mediates the cell cycle recruitment of SWI/SNF and RSC to the HIR-dependent histone genes.

In Saccharomyces cerevisiae, three out of the four histone gene pairs (HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2) are regulated by the HIR co-repressor complex. The histone chaperone Rtt106 has recently been shown to be present at these histone gene loci throughout the cell cycle in a HIR- and Asf1-dependent manner and involved in their transcriptional repression.

HIRIP3 antibody

70R-2185 50 ug
EUR 467
Description: Rabbit polyclonal HIRIP3 antibody raised against the middle region of HIRIP3

HIRIP3 Antibody

1-CSB-PA010372GA01HU
  • Ask for price
  • Ask for price
  • 150ul
  • 50ul
Description: A polyclonal antibody against HIRIP3. Recognizes HIRIP3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB, IHC

HIRIP3 Antibody

GWB-MV194E 50ug Ask for price

HIRIP3 Antibody

MBS9405517-01mL 0.1mL
EUR 420

HIRIP3 Antibody

MBS9405517-5x01mL 5x0.1mL
EUR 1740

HIRIP3 Antibody

MBS854494-01mg 0.1mg
EUR 345

HIRIP3 Antibody

MBS854494-01mLAF405L 0.1mL(AF405L)
EUR 565

HIRIP3 Antibody

MBS854494-01mLAF405S 0.1mL(AF405S)
EUR 565

HIRIP3 Antibody

MBS854494-01mLAF610 0.1mL(AF610)
EUR 565

HIRIP3 Antibody

MBS854494-01mLAF635 0.1mL(AF635)
EUR 565

HIRIP3 Antibody

MBS9434685-01mL 0.1mL
EUR 305

HIRIP3 Antibody

MBS9434685-5x01mL 5x0.1mL
EUR 1230

anti- HIRIP3 antibody

FNab03871 100µg
EUR 702
Description: Antibody raised against HIRIP3

HIRIP3 Antibody (Center)

MBS9203331-008mL 0.08mL
EUR 210

HIRIP3 Antibody (Center)

MBS9203331-04mL 0.4mL
EUR 430

HIRIP3 Antibody (Center)

MBS9203331-5x04mL 5x0.4mL
EUR 1910

Polyclonal HIRIP3 Antibody

APR02968G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIRIP3 . This antibody is tested and proven to work in the following applications:

HIRIP3 Polyclonal Antibody

30792-100ul 100ul
EUR 302.4

HIRIP3 Polyclonal Antibody

30792-50ul 50ul
EUR 224.4

HIRIP3 Polyclonal Antibody

E-AB-18848-120uL 120uL
EUR 240
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-18848-200uL 200uL
EUR 399
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-18848-20uL 20uL
EUR 73
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-18848-60uL 60uL
EUR 143
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-52761-120uL 120uL
EUR 240
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-52761-200uL 200uL
EUR 399
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-52761-20uL 20uL
EUR 73
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-52761-60uL 60uL
EUR 143
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-61469-120uL 120uL
EUR 320
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-61469-200uL 200uL
EUR 530
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-61469-60uL 60uL
EUR 200
Description: Unconjugated

HIRIP3 Polyclonal Antibody

E-AB-61469-each each Ask for price
Description: Unconjugated

HIRIP3 Polyclonal Antibody

MBS9127202-002mL 0.02mL
EUR 200

HIRIP3 Polyclonal Antibody

MBS9127202-005mL 0.05mL
EUR 255

HIRIP3 Polyclonal Antibody

MBS9127202-01mL 0.1mL
EUR 345

HIRIP3 Polyclonal Antibody

MBS9127202-02mL 0.2mL
EUR 545

HIRIP3 Polyclonal Antibody

MBS9127202-5x02mL 5x0.2mL
EUR 2265

HIRIP3 Polyclonal Antibody

MBS2562663-002mL 0.02mL
EUR 135

HIRIP3 Polyclonal Antibody

MBS2562663-006mL 0.06mL
EUR 190

HIRIP3 Polyclonal Antibody

MBS2562663-012mL 0.12mL
EUR 265

HIRIP3 Polyclonal Antibody

MBS2562663-02mL 0.2mL
EUR 415

HIRIP3 Polyclonal Antibody

MBS2562663-5x02mL 5x0.2mL
EUR 1835

HIRIP3 Polyclonal Antibody

MBS2560737-002mL 0.02mL
EUR 135

HIRIP3 Polyclonal Antibody

MBS2560737-006mL 0.06mL
EUR 190

HIRIP3 Polyclonal Antibody

MBS2560737-012mL 0.12mL
EUR 265

HIRIP3 Polyclonal Antibody

MBS2560737-02mL 0.2mL
EUR 415

HIRIP3 Polyclonal Antibody

MBS2560737-5x02mL 5x0.2mL
EUR 1835

HIRIP3 Polyclonal Antibody

MBS2536653-006mL 0.06mL
EUR 190

HIRIP3 Polyclonal Antibody

MBS2536653-012mL 0.12mL
EUR 265

HIRIP3 Polyclonal Antibody

MBS2536653-02mL 0.2mL
EUR 415

HIRIP3 Polyclonal Antibody

MBS2536653-5x02mL 5x0.2mL
EUR 1835

HIRIP3 Polyclonal Antibody

MBS9433923-005mL 0.05mL
EUR 300

HIRIP3 Polyclonal Antibody

MBS9433923-01mL 0.1mL
EUR 390

HIRIP3 Polyclonal Antibody

MBS9433923-5x01mL 5x0.1mL
EUR 1610

HIRIP3 Polyclonal Antibody

RD218848A-120uL 120μL
EUR 360
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD218848A-200uL 200μL
EUR 630
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD218848A-20uL 20μL
EUR 109.5
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD218848A-60uL 60μL
EUR 214.5
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD84223A-120uL 120μL
EUR 360
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD84223A-200uL 200μL
EUR 630
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD84223A-60uL 60μL
EUR 204
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD252761A-120uL 120μL
EUR 360
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD252761A-200uL 200μL
EUR 630
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD252761A-20uL 20μL
EUR 109.5
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 Polyclonal Antibody

RD252761A-60uL 60μL
EUR 214.5
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

HIRIP3 antibody - middle region

MBS3213825-01mL 0.1mL
EUR 455

HIRIP3 antibody - middle region

MBS3213825-5x01mL 5x0.1mL
EUR 1995

OAAN03627-50UL - HIRIP3 Antibody

OAAN03627-50UL 50ul
EUR 149

Polyclonal HIRIP3 Antibody (Center)

APR16639G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIRIP3 (Center). This antibody is tested and proven to work in the following applications:

OAAN03627-100UL - HIRIP3 Antibody

OAAN03627-100UL 100ul
EUR 249

OAAN03627-200UL - HIRIP3 Antibody

OAAN03627-200UL 200ul
EUR 389

HIRIP3 Rabbit Polyclonal Antibody

E10G32013 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HIRIP3 Rabbit Polyclonal Antibody

E10G02926 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HIRIP3 Rabbit Polyclonal Antibody

E10G09929 100 μl
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

HIRIP3 Antibody (Center) Blocking Peptide

MBS9223588-INQUIRE INQUIRE Ask for price

HIRIP3 Polyclonal Conjugated Antibody

C30792 100ul
EUR 476.4

HIRIP3 Polyclonal Conjugated Antibody

C31854 100ul
EUR 476.4

HIRIP3 Polyclonal Conjugated Antibody

MBS9441968-01mLAF350 0.1mL(AF350)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9441968-01mLAF405 0.1mL(AF405)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9441968-01mLAF488 0.1mL(AF488)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9441968-01mLAF555 0.1mL(AF555)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9441968-01mLBiotin 0.1mL(Biotin)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9443027-01mLAF350 0.1mL(AF350)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9443027-01mLAF405 0.1mL(AF405)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9443027-01mLAF488 0.1mL(AF488)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9443027-01mLAF555 0.1mL(AF555)
EUR 480

HIRIP3 Polyclonal Conjugated Antibody

MBS9443027-01mLBiotin 0.1mL(Biotin)
EUR 480

HIRA-Interacting Protein 3 (HIRIP3) Antibody

20-abx113016
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

HIRA-Interacting Protein 3 (HIRIP3) Antibody

20-abx005315
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx037953-100ug 100 ug
EUR 469.2

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx030421-400ul 400 ul
EUR 627.6

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx030421-80l 80 µl
EUR 343.2

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx233871-100ug 100 ug
EUR 661.2

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx113016-100l 100 µl
EUR 612.5

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx037953-100g 100 µg
EUR 337.5

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx030421-400l 400 µl
EUR 518.75

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx233871-100g 100 µg
EUR 350

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx005315-100l 100 µl
EUR 400

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx005315-20l 20 µl
EUR 175

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx005315-50l 50 µl
EUR 275

ARP58286_P050-25UL - HIRIP3 Antibody - middle region

ARP58286_P050-25UL 25ul
EUR 99

HIRIP3

CSB-CL883612HU 10 μg plasmid + 200μl Glycerol Ask for price

HIRIP3

MBS8536180-01mL 0.1mL
EUR 325

HIRIP3

MBS8536180-01mLAF405L 0.1mL(AF405L)
EUR 565

HIRIP3

MBS8536180-01mLAF405S 0.1mL(AF405S)
EUR 565

HIRIP3

MBS8536180-01mLAF610 0.1mL(AF610)
EUR 565

HIRIP3

MBS8536180-01mLAF635 0.1mL(AF635)
EUR 565

ARP58286_P050 - HIRIP3 antibody - middle region (ARP58286_P050)

ARP58286_P050 100ul
EUR 389

Mouse monoclonal antibody Anti-Human HIRIP3

MBS120315-01mg 0.1mg
EUR 470

Mouse monoclonal antibody Anti-Human HIRIP3

MBS120315-5x01mg 5x0.1mg
EUR 2080

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3)

MBS6002458-02mL 0.2(mL
EUR 695

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3)

MBS6002458-5x02mL 5x0.2mL
EUR 2975

HIRIP3 siRNA

20-abx919397
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

HIRIP3 siRNA

20-abx919398
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (AP)

MBS6306626-02mL 0.2mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (AP)

MBS6306626-5x02mL 5x0.2mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (PE)

MBS6306636-02mL 0.2mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (PE)

MBS6306636-5x02mL 5x0.2mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (APC)

MBS6306627-02mL 0.2mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (APC)

MBS6306627-5x02mL 5x0.2mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (FITC)

MBS6306629-02mL 0.2mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (FITC)

MBS6306629-5x02mL 5x0.2mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (Biotin)

MBS6306628-02mL 0.2mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (Biotin)

MBS6306628-5x02mL 5x0.2mL
EUR 4250

HIRIP3 (untagged)-Human HIRA interacting protein 3 (HIRIP3)

SC117881 10 µg Ask for price

HIRIP3 (untagged)-Human HIRA interacting protein 3 (HIRIP3)

SC324592 10 µg Ask for price

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 405)

MBS6306631-01mL 0.1mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 405)

MBS6306631-5x01mL 5x0.1mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 490)

MBS6306632-01mL 0.1mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 490)

MBS6306632-5x01mL 5x0.1mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 550)

MBS6306633-01mL 0.1mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 550)

MBS6306633-5x01mL 5x0.1mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 650)

MBS6306634-01mL 0.1mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 650)

MBS6306634-5x01mL 5x0.1mL
EUR 4250

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 750)

MBS6306635-01mL 0.1mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (MaxLight 750)

MBS6306635-5x01mL 5x0.1mL
EUR 4250

Hirip3 (GFP-tagged) - Mouse HIRA interacting protein 3 (Hirip3)

MG209311 10 µg Ask for price

HIRIP3 (GFP-tagged) - Human HIRA interacting protein 3 (HIRIP3)

RG200510 10 µg Ask for price

Hirip3 (untagged) - Mouse HIRA interacting protein 3 (Hirip3), (10ug)

MC219487 10 µg Ask for price

HIRIP3 Rabbit pAb

A7014-200ul 200 ul
EUR 550.8

HIRIP3 Rabbit pAb

A7014-20ul 20 ul
EUR 219.6

HIRIP3 Rabbit pAb

E2507014 100ul
EUR 225
Description: Available in various conjugation types.

HIRIP3 cDNA Clone

MBS1266829-001mgPlasmid02mLGlycerolStock 0.01mgPlasmid+0.2mLGlycerol-Stock
EUR 330

HIRIP3 cDNA Clone

MBS1266829-5x001mgPlasmid5x02mLGlycerolStock 5x0.01mgPlasmid+5x0.2mLGlycerol-Stock
EUR 1430

HIRIP3 Rabbit pAb

MBS8546513-01mL 0.1mL
EUR 305

HIRIP3 Rabbit pAb

MBS8546513-01mLAF405L 0.1mL(AF405L)
EUR 565

HIRIP3 Rabbit pAb

MBS8546513-01mLAF405S 0.1mL(AF405S)
EUR 565

HIRIP3 Rabbit pAb

MBS8546513-01mLAF610 0.1mL(AF610)
EUR 565

HIRIP3 Rabbit pAb

MBS8546513-01mLAF635 0.1mL(AF635)
EUR 565

HIRIP3 Rabbit pAb

A7014 50μL
EUR 262.15

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (Azide free) (HRP)

MBS6306630-02mL 0.2mL
EUR 980

HIRIP3, ID (HIRIP3, HIRA-interacting protein 3) (Azide free) (HRP)

MBS6306630-5x02mL 5x0.2mL
EUR 4250

HIRIP3 siRNA (Human)

MBS8230588-15nmol 15nmol
EUR 405

HIRIP3 siRNA (Human)

MBS8230588-30nmol 30nmol
EUR 565

HIRIP3 siRNA (Human)

MBS8230588-5x30nmol 5x30nmol
EUR 2450

HIRIP3 siRNA (Mouse)

MBS8220953-15nmol 15nmol
EUR 405

HIRIP3 siRNA (Mouse)

MBS8220953-30nmol 30nmol
EUR 565

HIRIP3 siRNA (Mouse)

MBS8220953-5x30nmol 5x30nmol
EUR 2450

Hirip3 (Myc-DDK-tagged) - Mouse HIRA interacting protein 3 (Hirip3)

MR209311 10 µg Ask for price

HIRIP3 (Myc-DDK-tagged)-Human HIRA interacting protein 3 (HIRIP3)

RC200510 10 µg Ask for price

HIRIP3 cloning plasmid

CSB-CL883612HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the HIRIP3 gene.

Hirip3 (untagged ORF) - Rat HIRA interacting protein 3 (Hirip3), (10 ug)

RN200696 10 µg Ask for price

HIRIP3 Blocking Peptide

33R-8235 100 ug
EUR 119
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HIRIP3 antibody, catalog no. 70R-2185

Human HIRIP3 ELISA KIT

EF010125 96tests
EUR 566

HIRIP3 (Center) Rabbit pAb

E2613959 100ul
EUR 225
Description: Available in various conjugation types.

HIRIP3 (Center) Rabbit pAb

MBS8553248-01mL 0.1mL
EUR 305

HIRIP3 (Center) Rabbit pAb

MBS8553248-01mLAF405L 0.1mL(AF405L)
EUR 565

HIRIP3 (Center) Rabbit pAb

MBS8553248-01mLAF405S 0.1mL(AF405S)
EUR 565

HIRIP3 (Center) Rabbit pAb

MBS8553248-01mLAF610 0.1mL(AF610)
EUR 565

HIRIP3 (Center) Rabbit pAb

MBS8553248-01mLAF635 0.1mL(AF635)
EUR 565

Hirip3 (Myc-DDK-tagged ORF) - Rat HIRA interacting protein 3 (Hirip3), (10 ug)

RR200696 10 µg Ask for price

Mouse HIRIP3 shRNA Plasmid

20-abx982088
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human HIRIP3 shRNA Plasmid

20-abx955558
  • Ask for price
  • Ask for price
  • 150 µg
  • 300 µg

Human HIRIP3 Protein Lysate

MBS8412938-002mg 0.02mg
EUR 365

Human HIRIP3 Protein Lysate

MBS8412938-5x002mg 5x0.02mg
EUR 1410

HIRIP3 (NM_003609) Human Recombinant Protein

PROTQ9BW71 20ug
EUR 1249
Description: Recombinant protein of human HIRA interacting protein 3 (HIRIP3)

HIRIP3 Peptide - middle region

MBS3238764-01mg 0.1mg
EUR 180

HIRIP3 Peptide - middle region

MBS3238764-5x01mg 5x0.1mg
EUR 730

HIRIP3 (untagged) - Homo sapiens HIRA interacting protein 3 (HIRIP3), transcript variant 2

SC331200 10 µg Ask for price

Lenti ORF clone of Hirip3 (mGFP-tagged) - Mouse HIRA interacting protein 3 (Hirip3)

MR209311L4 10 µg Ask for price

HIRIP3 Recombinant Protein (Rat)

RP204605 100 ug Ask for price

HIRIP3 Recombinant Protein (Human)

RP014686 100 ug Ask for price

HIRIP3 Recombinant Protein (Mouse)

RP141530 100 ug Ask for price

HIRIP3 (GFP-tagged) - Homo sapiens HIRA interacting protein 3 (HIRIP3), transcript variant 2

RG233362 10 µg Ask for price

Hirip3 ORF Vector (Rat) (pORF)

ORF068203 1.0 ug DNA
EUR 607.2

Lenti ORF clone of Hirip3 (Myc-DDK-tagged) - Mouse HIRA interacting protein 3 (Hirip3)

MR209311L3 10 µg Ask for price

Hirip3 ORF Vector (Mouse) (pORF)

ORF047178 1.0 ug DNA
EUR 607.2
The SWI/SNF and RSC chromatin remodeling complexes are both recruited to the HIR-dependent histone genes; SWI/SNF is required for their activation in S phase, whereas RSC is implicated in their repression outside of S phase. Even though their presence at the histone genes is dependent on the HIR complex, their specific recruitment has not been well characterized. In this study we focused on characterizing the role played by the histone chaperone Rtt106 in the cell cycle-dependent recruitment of SWI/SNF and RSC complexes to the histone genes.

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