The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.

RNA polymerase II initiates from low complexity sequences so cells must reliably distinguish “real” from “cryptic” promoters and maintain fidelity to the former. Further, this must be performed under a range of conditions, including those found within inactive and highly transcribed regions. Here, we used genome-scale screening to identify those factors that regulate the use of a specific cryptic promoter and how this is influenced by the degree of transcription over the element.
We show that promoter fidelity is most reliant on histone gene transactivators (Spt10, Spt21) and H3-H4 chaperones (Asf1, HIR complex) from the replication-independent deposition pathway. Mutations of Rtt106 that abrogate its interactions with H3-H4 or dsDNA permit extensive cryptic transcription comparable with replication-independent deposition factor deletions. We propose that nucleosome shielding is the primary means to maintain promoter fidelity, and histone replacement is most efficiently mediated in yeast cells by a HIR/Asf1/H3-H4/Rtt106 pathway.

Physical association of Arabidopsis hypersensitive induced reaction proteins (HIRs) with the immune receptor RPS2.

Arabidopsis RPS2 is a typical nucleotide-binding leucine-rich repeat resistance protein, which indirectly recognizes the bacterial effector protein AvrRpt2 and thereby activates effector-triggered immunity (ETI). Previously, we identified two hypersensitive induced reaction (AtHIR) proteins, AtHIR1 (At1g09840) and AtHIR2 (At3g01290), as potential RPS2 complex components.
AtHIR proteins contain the stomatin/prohibitin/flotillin/HflK/C domain (also known as the prohibitin domain or band 7 domain). In this study, we confirmed that AtHIR1 and AtHIR2 form complexes with RPS2 in Arabidopsis and Nicotiana benthamiana using a pulldown assay and fluorescence resonance energy transfer (FRET) analysis.
Arabidopsis has four HIR family genes (AtHIR1-4). All AtHIR proteins could form homo- and hetero-oligomers in vivo and were enriched in membrane microdomains of the plasma membrane. The mRNA levels of all except AtHIR4 were significantly induced by microbe-associated molecular patterns, such as the bacterial flagellin fragment flg22.
Athir2-1 and Athir3-1 mutants allowed more growth of Pto DC3000 AvrRpt2, but not Pto DC3000, indicating that these mutations reduce RPS2-mediated ETI but do not affect basal resistance to the virulent strain. Overexpression of AtHIR1 and AtHIR2 reduced growth of Pto DC3000. Taken together, the results show that the AtHIR proteins are physically associated with RPS2, are localized in membrane microdomains, and quantitatively contribute to RPS2-mediated ETI.

Separation-of-function mutation in HPC2, a member of the HIR complex in S. cerevisiae, results in derepression of the histone genes but does not confer cryptic TATA phenotypes.

The HIR complex, which is comprised of the four proteins Hir1, Hir2, Hir3 and Hpc2, was first characterized as a repressor of three of the four histone gene loci in Saccharomyces cerevisiae. Using a bioinformatical approach, previous studies have identified a region of Hpc2 that is conserved in Schizosaccharomyces pombe and humans. Using a similar approach, we identified two additional domains, CDI and CDII, of the Hpc2 protein that are conserved among yeast species related to S. cerevisiae.
 The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity.
We showed that the N terminal CDI domain (spanning amino acids 63-79) is dispensable for HIR complex assembly, but plays an essential role in the repression of the histone genes by recruiting the HIR complex to the HIR-dependent histone gene loci. The second conserved domain, CDII (spanning amino acids 452-480), is required for the stability of the Hpc2 protein itself as well as for the assembly of the HIR complex.
In addition, we report a novel separation-of-function mutation within CDI of Hpc2, which causes derepression of the histone genes but does not confer other reported hir/hpc- phenotypes (such as Spt phenotypes, heterochromatin silencing defects and repression of cryptic promoters). This is the first direct demonstration that a separation-of-function mutation exists within the HIR complex.

The Saccharomyces cerevisiae histone chaperone Rtt106 mediates the cell cycle recruitment of SWI/SNF and RSC to the HIR-dependent histone genes.

In Saccharomyces cerevisiae, three out of the four histone gene pairs (HTA1-HTB1, HHT1-HHF1, and HHT2-HHF2) are regulated by the HIR co-repressor complex. The histone chaperone Rtt106 has recently been shown to be present at these histone gene loci throughout the cell cycle in a HIR- and Asf1-dependent manner and involved in their transcriptional repression.

Polyclonal HIRIP3 Antibody

APR02968G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIRIP3 . This antibody is tested and proven to work in the following applications:

HIRIP3 Polyclonal Antibody

30792-100ul 100ul
EUR 302.4

HIRIP3 Polyclonal Antibody

30792-50ul 50ul
EUR 224.4

Polyclonal HIRIP3 Antibody (Center)

APR16639G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human HIRIP3 (Center). This antibody is tested and proven to work in the following applications:

HIRIP3 Polyclonal Conjugated Antibody

C31854 100ul
EUR 476.4

HIRIP3 Polyclonal Conjugated Antibody

C30792 100ul
EUR 476.4

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx233871-100ug 100 ug
EUR 661.2

HIRA-Interacting Protein 3 (HIRIP3) Antibody

20-abx113016
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx030421-400ul 400 ul
EUR 627.6

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx030421-80l 80 µl
EUR 343.2

HIRA-Interacting Protein 3 (HIRIP3) Antibody

abx037953-100ug 100 ug
EUR 469.2

HIRA-Interacting Protein 3 (HIRIP3) Antibody

20-abx005315
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

HIRIP3 siRNA

20-abx919397
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

HIRIP3 siRNA

20-abx919398
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

HIRIP3 Rabbit pAb

A7014-100ul 100 ul
EUR 369.6

HIRIP3 Rabbit pAb

A7014-200ul 200 ul
EUR 550.8

HIRIP3 Rabbit pAb

A7014-20ul 20 ul
EUR 219.6

HIRIP3 Rabbit pAb

A7014-50ul 50 ul
EUR 267.6

HIRIP3 cloning plasmid

CSB-CL883612HU-10ug 10ug
EUR 451.2
Description: A cloning plasmid for the HIRIP3 gene.

HIRIP3 Blocking Peptide

33R-8235 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HIRIP3 antibody, catalog no. 70R-2185

HIRIP3 ELISA KIT|Human

EF010125 96 Tests
EUR 826.8

Human HIRIP3 shRNA Plasmid

20-abx955558
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse HIRIP3 shRNA Plasmid

20-abx982088
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

HIRIP3 Recombinant Protein (Rat)

RP204605 100 ug Ask for price

Hirip3 ORF Vector (Rat) (pORF)

ORF068203 1.0 ug DNA
EUR 607.2

HIRIP3 Recombinant Protein (Human)

RP014686 100 ug Ask for price

HIRIP3 Recombinant Protein (Mouse)

RP141530 100 ug Ask for price

HIRIP3 ORF Vector (Human) (pORF)

ORF004896 1.0 ug DNA
EUR 114

Hirip3 ORF Vector (Mouse) (pORF)

ORF047178 1.0 ug DNA
EUR 607.2

Hirip3 3'UTR GFP Stable Cell Line

TU159519 1.0 ml Ask for price

HIRIP3 3'UTR GFP Stable Cell Line

TU059797 1.0 ml
EUR 1672.8

Hirip3 3'UTR GFP Stable Cell Line

TU255784 1.0 ml Ask for price

Hirip3 sgRNA CRISPR Lentivector set (Rat)

K7156001 3 x 1.0 ug
EUR 406.8

Hirip3 sgRNA CRISPR Lentivector set (Mouse)

K4629701 3 x 1.0 ug
EUR 406.8

HIRIP3 sgRNA CRISPR Lentivector set (Human)

K0953201 3 x 1.0 ug
EUR 406.8

HIRIP3 Protein Vector (Rat) (pPM-C-HA)

PV272812 500 ng
EUR 723.6

HIRIP3 Protein Vector (Rat) (pPB-C-His)

PV272810 500 ng
EUR 723.6

HIRIP3 Protein Vector (Rat) (pPB-N-His)

PV272811 500 ng
EUR 723.6

HIRIP3 Protein Vector (Rat) (pPM-C-His)

PV272813 500 ng
EUR 723.6

HIRIP3 Protein Vector (Human) (pPM-C-HA)

PV019583 500 ng
EUR 394.8

HIRIP3 Protein Vector (Mouse) (pPM-C-HA)

PV188712 500 ng
EUR 723.6

HIRIP3 Protein Vector (Human) (pPB-C-His)

PV019581 500 ng
EUR 394.8

HIRIP3 Protein Vector (Human) (pPB-N-His)

PV019582 500 ng
EUR 394.8

HIRIP3 Protein Vector (Human) (pPM-C-His)

PV019584 500 ng
EUR 394.8

HIRIP3 Protein Vector (Mouse) (pPB-C-His)

PV188710 500 ng
EUR 723.6

HIRIP3 Protein Vector (Mouse) (pPB-N-His)

PV188711 500 ng
EUR 723.6

HIRIP3 Protein Vector (Mouse) (pPM-C-His)

PV188713 500 ng
EUR 723.6

HIRIP3 3'UTR Luciferase Stable Cell Line

TU009797 1.0 ml
EUR 1672.8

Hirip3 3'UTR Luciferase Stable Cell Line

TU109519 1.0 ml Ask for price

Hirip3 3'UTR Luciferase Stable Cell Line

TU205784 1.0 ml Ask for price

Hirip3 sgRNA CRISPR Lentivector (Rat) (Target 1)

K7156002 1.0 ug DNA
EUR 184.8

Hirip3 sgRNA CRISPR Lentivector (Rat) (Target 2)

K7156003 1.0 ug DNA
EUR 184.8

Hirip3 sgRNA CRISPR Lentivector (Rat) (Target 3)

K7156004 1.0 ug DNA
EUR 184.8

Hirip3 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4629702 1.0 ug DNA
EUR 184.8

Hirip3 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4629703 1.0 ug DNA
EUR 184.8

Hirip3 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4629704 1.0 ug DNA
EUR 184.8

HIRIP3 sgRNA CRISPR Lentivector (Human) (Target 1)

K0953202 1.0 ug DNA
EUR 184.8

HIRIP3 sgRNA CRISPR Lentivector (Human) (Target 2)

K0953203 1.0 ug DNA
EUR 184.8

HIRIP3 sgRNA CRISPR Lentivector (Human) (Target 3)

K0953204 1.0 ug DNA
EUR 184.8

Human HIRA- interacting protein 3, HIRIP3 ELISA KIT

ELI-38603h 96 Tests
EUR 988.8

Mouse HIRA- interacting protein 3, Hirip3 ELISA KIT

ELI-14456m 96 Tests
EUR 1038

Human HIRA-Interacting Protein 3 (HIRIP3) ELISA Kit

abx387793-96tests 96 tests
EUR 1093.2

HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV627643 1.0 ug DNA
EUR 818.4

HIRIP3 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV627647 1.0 ug DNA
EUR 818.4

HIRIP3 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV627648 1.0 ug DNA
EUR 818.4

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K7156005 3 x 1.0 ug
EUR 451.2

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K4629705 3 x 1.0 ug
EUR 451.2

HIRIP3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0953205 3 x 1.0 ug
EUR 451.2

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K7156006 1.0 ug DNA
EUR 200.4

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K7156007 1.0 ug DNA
EUR 200.4

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K7156008 1.0 ug DNA
EUR 200.4

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K4629706 1.0 ug DNA
EUR 200.4

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K4629707 1.0 ug DNA
EUR 200.4

Hirip3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K4629708 1.0 ug DNA
EUR 200.4

HIRIP3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0953206 1.0 ug DNA
EUR 200.4

HIRIP3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0953207 1.0 ug DNA
EUR 200.4

HIRIP3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0953208 1.0 ug DNA
EUR 200.4

HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV627644 1.0 ug DNA
EUR 818.4

HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV627645 1.0 ug DNA
EUR 888

HIRIP3 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV627646 1.0 ug DNA
EUR 888

Anti-HIRIP3 antibody

PAab03871 100 ug
EUR 494.4

Anti-HIRIP3 antibody

STJ29094 100 µl
EUR 332.4
Description: The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

anti-HIRIP3

YF-PA15655 50 ul
EUR 435.6
Description: Mouse polyclonal to HIRIP3

anti-HIRIP3

YF-PA15656 50 ug
EUR 435.6
Description: Mouse polyclonal to HIRIP3

Anti-HIRIP3 (3B3)

YF-MA11069 100 ug
EUR 435.6
Description: Mouse monoclonal to HIRIP3

pOTB7-HIRIP3

PVT18716 2 ug
EUR 277.2

HIRA Antibody

43121-100ul 100ul
EUR 302.4

HIRA antibody

70R-35843 100 ug
EUR 392.4
Description: Rabbit polyclonal HIRA antibody

HIRA Antibody

1-CSB-PA060030
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against HIRA. Recognizes HIRA from Human, Mouse. This antibody is Unconjugated. Tested in the following application: IHC, ELISA;IHC:1/100-1/300.ELISA:1/10000

HIRA Antibody

DF13473 100ul
EUR 420

Hirudin Antibody

abx023282-2ml 2 ml
EUR 526.8

PE Anti-human CD235 Antibody *HIR2*

123511M0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD235 Antibody *HIR2*

123511M1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD235 Antibody *HIR2*

123511M2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE Anti-human CD235 Antibody *HIR2*

123511M0-25tests 25 tests
EUR 179
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE Anti-human CD235 Antibody *HIR2*

123511M1-100tests 100 tests
EUR 505
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE Anti-human CD235 Antibody *HIR2*

123511M2-500tests 500 tests
EUR 1887
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

APC Anti-human CD235 Antibody *HIR2*

123511C0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD235 Antibody *HIR2*

123511C1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD235 Antibody *HIR2*

123511C2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC Anti-human CD235 Antibody *HIR2*

123511C0-25tests 25 tests
EUR 179
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

APC Anti-human CD235 Antibody *HIR2*

123511C1-100tests 100 tests
EUR 505
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

APC Anti-human CD235 Antibody *HIR2*

123511C2-500tests 500 tests
EUR 1887
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

FITC Anti-human CD235 Antibody *HIR2*

123511I0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD235 Antibody *HIR2*

123511I1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

FITC Anti-human CD235 Antibody *HIR2*

123511I0-100tests 100 tests
EUR 245
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

FITC Anti-human CD235 Antibody *HIR2*

123511I1-500tests 500 tests
EUR 918
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE/Cy5 Anti-human CD235 Antibody *HIR2*

123511N0 25 tests
EUR 210
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy5 Anti-human CD235 Antibody *HIR2*

123511N1 100 tests
EUR 587
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy5 Anti-human CD235 Antibody *HIR2*

123511N2 500 tests
EUR 1989
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy7 Anti-human CD235 Antibody *HIR2*

123511O0 25 tests
EUR 210
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy7 Anti-human CD235 Antibody *HIR2*

123511O1 100 tests
EUR 587
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy7 Anti-human CD235 Antibody *HIR2*

123511O2 500 tests
EUR 1989
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PE/Cy5 Anti-human CD235 Antibody *HIR2*

123511N0-25tests 25 tests
EUR 210
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE/Cy5 Anti-human CD235 Antibody *HIR2*

123511N1-100tests 100 tests
EUR 587
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE/Cy5 Anti-human CD235 Antibody *HIR2*

123511N2-500tests 500 tests
EUR 1989
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE/Cy7 Anti-human CD235 Antibody *HIR2*

123511O0-25tests 25 tests
EUR 210
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE/Cy7 Anti-human CD235 Antibody *HIR2*

123511O1-100tests 100 tests
EUR 587
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PE/Cy7 Anti-human CD235 Antibody *HIR2*

123511O2-500tests 500 tests
EUR 1989
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

TRITC Anti-human CD235 Antibody *HIR2*

123511J0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

TRITC Anti-human CD235 Antibody *HIR2*

123511J1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD235 Antibody *HIR2*

123511V0 25 tests
EUR 179
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD235 Antibody *HIR2*

123511V1 100 tests
EUR 505
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP Anti-human CD235 Antibody *HIR2*

123511V2 500 tests
EUR 1887
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

TRITC Anti-human CD235 Antibody *HIR2*

123511J0-100tests 100 tests
EUR 245
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

TRITC Anti-human CD235 Antibody *HIR2*

123511J1-500tests 500 tests
EUR 918
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PerCP Anti-human CD235 Antibody *HIR2*

123511V0-25tests 25 tests
EUR 179
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PerCP Anti-human CD235 Antibody *HIR2*

123511V1-100tests 100 tests
EUR 505
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PerCP Anti-human CD235 Antibody *HIR2*

123511V2-500tests 500 tests
EUR 1887
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

APC/Cy7 Anti-human CD235 Antibody *HIR2*

123511D0 25 tests
EUR 210
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC/Cy7 Anti-human CD235 Antibody *HIR2*

123511D1 100 tests
EUR 587
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC/Cy7 Anti-human CD235 Antibody *HIR2*

123511D2 500 tests
EUR 1989
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

APC/Cy7 Anti-human CD235 Antibody *HIR2*

123511D0-25tests 25 tests
EUR 210
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

APC/Cy7 Anti-human CD235 Antibody *HIR2*

123511D1-100tests 100 tests
EUR 587
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

APC/Cy7 Anti-human CD235 Antibody *HIR2*

123511D2-500tests 500 tests
EUR 1989
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

HIRA antibody (Thr555)

70R-35492 100 ug
EUR 392.4
Description: Purified Rabbit polyclonal HIRA antibody (Thr555)

PacBlue Anti-human CD235 Antibody *HIR2*

123511K0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacBlue Anti-human CD235 Antibody *HIR2*

123511K1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacBlue Anti-human CD235 Antibody *HIR2*

123511K0-100tests 100 tests
EUR 245
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PacBlue Anti-human CD235 Antibody *HIR2*

123511K1-500tests 500 tests
EUR 918
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PerCP/Cy5.5 Anti-human CD235 Antibody *HIR2*

123511W0 25 tests
EUR 210
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP/Cy5.5 Anti-human CD235 Antibody *HIR2*

123511W1 100 tests
EUR 587
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP/Cy5.5 Anti-human CD235 Antibody *HIR2*

123511W2 500 tests
EUR 1989
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PerCP/Cy5.5 Anti-human CD235 Antibody *HIR2*

123511W0-25tests 25 tests
EUR 210
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PerCP/Cy5.5 Anti-human CD235 Antibody *HIR2*

123511W1-100tests 100 tests
EUR 587
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PerCP/Cy5.5 Anti-human CD235 Antibody *HIR2*

123511W2-500tests 500 tests
EUR 1989
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

Purified Anti-human CD235 Antibody *HIR2*

12351000 100 ug
EUR 164
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

Purified Anti-human CD235 Antibody *HIR2*

12351000-100ug 100 ug
EUR 164
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PacOrange Anti-human CD235 Antibody *HIR2*

123511L0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacOrange Anti-human CD235 Antibody *HIR2*

123511L1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

PacOrange Anti-human CD235 Antibody *HIR2*

123511L0-100tests 100 tests
EUR 245
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

PacOrange Anti-human CD235 Antibody *HIR2*

123511L1-500tests 500 tests
EUR 918
Description: HIR2 is an anti-human monoclonal antibody that targets the CD235a antigen.

iFluor® 350 Anti-human CD235 Antibody *HIR2*

12351010 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 350 Anti-human CD235 Antibody *HIR2*

12351011 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 405 Anti-human CD235 Antibody *HIR2*

12351020 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 405 Anti-human CD235 Antibody *HIR2*

12351021 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 430 Anti-human CD235 Antibody *HIR2*

12351030 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 430 Anti-human CD235 Antibody *HIR2*

12351031 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 450 Anti-human CD235 Antibody *HIR2*

12351040 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 450 Anti-human CD235 Antibody *HIR2*

12351041 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 488 Anti-human CD235 Antibody *HIR2*

12351050 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 488 Anti-human CD235 Antibody *HIR2*

12351051 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 514 Anti-human CD235 Antibody *HIR2*

12351060 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 514 Anti-human CD235 Antibody *HIR2*

12351061 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 532 Anti-human CD235 Antibody *HIR2*

12351070 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 532 Anti-human CD235 Antibody *HIR2*

12351071 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 546 Anti-human CD235 Antibody *HIR2*

12351080 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 546 Anti-human CD235 Antibody *HIR2*

12351081 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 555 Anti-human CD235 Antibody *HIR2*

12351090 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 555 Anti-human CD235 Antibody *HIR2*

12351091 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 560 Anti-human CD235 Antibody *HIR2*

123510A0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 560 Anti-human CD235 Antibody *HIR2*

123510A1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 568 Anti-human CD235 Antibody *HIR2*

123510B0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 568 Anti-human CD235 Antibody *HIR2*

123510B1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 594 Anti-human CD235 Antibody *HIR2*

123510C0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 594 Anti-human CD235 Antibody *HIR2*

123510C1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 610 Anti-human CD235 Antibody *HIR2*

123510D0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 610 Anti-human CD235 Antibody *HIR2*

123510D1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 633 Anti-human CD235 Antibody *HIR2*

123510E0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 633 Anti-human CD235 Antibody *HIR2*

123510E1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 647 Anti-human CD235 Antibody *HIR2*

123510F0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 647 Anti-human CD235 Antibody *HIR2*

123510F1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 660 Anti-human CD235 Antibody *HIR2*

123510G0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 660 Anti-human CD235 Antibody *HIR2*

123510G1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 670 Anti-human CD235 Antibody *HIR2*

123510H0 100 tests
EUR 245
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn

iFluor® 670 Anti-human CD235 Antibody *HIR2*

123510H1 500 tests
EUR 918
Description: R-Phrase for Dangerous Goods accord. to EU 67/548 EWG: R20, R21, R22; H-Phrases (GHS) for Dangerous Goods accord. to 1272/2008: H303, H313, H333; Symbol for Dangerous Compound accord. to EU 67/548 EWG: Xn
The SWI/SNF and RSC chromatin remodeling complexes are both recruited to the HIR-dependent histone genes; SWI/SNF is required for their activation in S phase, whereas RSC is implicated in their repression outside of S phase. Even though their presence at the histone genes is dependent on the HIR complex, their specific recruitment has not been well characterized. In this study we focused on characterizing the role played by the histone chaperone Rtt106 in the cell cycle-dependent recruitment of SWI/SNF and RSC complexes to the histone genes.

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